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show all sequences of 1.1.1.29

Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis

Subramanian, V.S.; Nabokina, S.M.; Patton, J.R.; Marchant, J.S.; Moradi, H.; Said, H.M.; Am. J. Physiol. Gastrointest. Liver Physiol. 304, G1079-G1086 (2013)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hydroxypyruvate + NADH + H+
Homo sapiens
-
D-glycerate + NAD+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
glutathione-Sepharose 4B bead column chromatography, and Superdex 200 gel filtration
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
ARPE-19 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hydroxypyruvate + NADH + H+
-
737421
Homo sapiens
D-glycerate + NAD+
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 37000, SDS-PAGE
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hydroxypyruvate + NADH + H+
Homo sapiens
-
D-glycerate + NAD+
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
glutathione-Sepharose 4B bead column chromatography, and Superdex 200 gel filtration
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
ARPE-19 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hydroxypyruvate + NADH + H+
-
737421
Homo sapiens
D-glycerate + NAD+
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 37000, SDS-PAGE
Homo sapiens
General Information
General Information
Commentary
Organism
malfunction
enzyme knockdown leads to an inhibition of ascorbic acid uptake
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
enzyme knockdown leads to an inhibition of ascorbic acid uptake
Homo sapiens
Other publictions for EC 1.1.1.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737421
Subramanian
Glyoxalate reductase/hydroxypy ...
Homo sapiens
Am. J. Physiol. Gastrointest. Liver Physiol.
304
G1079-G1086
2013
-
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1
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3
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1
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1
1
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737736
Corpas
Inhibition of peroxisomal hydr ...
Arabidopsis thaliana
Biochim. Biophys. Acta
1830
4981-4989
2013
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1
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4
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1
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1
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737745
Hoover
Identification of catalyticall ...
Arabidopsis thaliana
Biochim. Biophys. Acta
1834
2663-2671
2013
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739241
Pan
Glyoxylate reductase/hydroxypy ...
Homo sapiens
Pathobiology
80
155-162
2013
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1
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1
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2
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6
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1
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6
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1
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1
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1
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726102
Cousins
Peroxisomal hydroxypyruvate re ...
Arabidopsis thaliana
Photosyn. Res.
108
91-100
2011
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1
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1
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728436
Kern
Evolution of enzymes involved ...
Arabidopsis thaliana
Photosyn. Res.
109
103-114
2011
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286509
Julliard
Identification of hydroxypyruv ...
Petroselinum crispum
Protein Expr. Purif.
9
10-14
1997
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2
1
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2
1
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1
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286510
Hagishita
Immunological characterization ...
Hyphomicrobium methylovorum
FEMS Microbiol. Lett.
142
49-52
1996
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286505
Kleczkowski
Oxalate as a potent and select ...
Hordeum vulgare, Zea mays
Biochem. J.
276
125-127
1991
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286508
Chistoserdova
Purification and characterizat ...
Methylobacterium extorquens
J. Bacteriol.
173
7228-7232
1991
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3
7
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2
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286506
Izumi
Purification and characterizat ...
Hyphomicrobium methylovorum
Eur. J. Biochem.
190
279-284
1990
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8
3
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4
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8
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286507
Stafford
The enzymatic reduction of hyd ...
Beta vulgaris, Brassica oleracea, Daucus carota, Lactuca sativa, Petroselinum crispum, Pisum sativum, Raphanus sativus, Solanum lycopersicum, Spinacia oleracea
J. Biol. Chem.
207
621-629
1954
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9
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18
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18
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9
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9
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9
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