1.1.1.224: mannose-6-phosphate 6-reductase

This is an abbreviated version, for detailed information about mannose-6-phosphate 6-reductase, go to the full flat file.

Reaction

D-mannitol 1-phosphate
+
NADP+
=
D-mannose 6-phosphate
+
NADPH
+
H+

Synonyms

6-phosphomannose reductase, M6PR, mannose 6-phosphate reductase, mannose-6-phosphate reductase, NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase, NADPH-dependent M6P reductase, NADPH-dependent mannose 6-phosphate reductase, NADPH-mannose-6-P reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.224 mannose-6-phosphate 6-reductase

Inhibitors

Inhibitors on EC 1.1.1.224 - mannose-6-phosphate 6-reductase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NaCl
-
47% reduction by 100 mM
siRNA
-
transformed tomato plants containing siRNA from the M6PR of Orobanche aegyptiaca show normal growth and development, accumulation of M6PR siRNA in transgenic tomatoes correlates with decreased levels of M6PR mRNA. Amount of endogenous M6PR mRNA in the tubercles and underground shoots of Orobanche aegyptiaca grown on transgenic host plants is reduced by 60%-80%. Concomitant with M6PR mRNA suppression, there is a significant decrease in mannitol level and a significant increase in the percentage of dead Orobanche aegyptiaca tubercles on the transgenic host plants. Detection of mir390, which is involved with cytoplasmic dsRNA processing, indicates to the existence of gene-silencing mechanisms in Orobanche spp. Gene silencing mechanisms are probably involved with the production of decreased levels of M6PR mRNA in the parasites grown on the transformed tomato lines
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additional information
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overview over substrate and product analogues
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