1.1.1.224: mannose-6-phosphate 6-reductase

This is an abbreviated version, for detailed information about mannose-6-phosphate 6-reductase, go to the full flat file.

Reaction

D-mannitol 1-phosphate
+
NADP+
=
D-mannose 6-phosphate
+
NADPH
+
H+

Synonyms

6-phosphomannose reductase, M6PR, mannose 6-phosphate reductase, mannose-6-phosphate reductase, NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase, NADPH-dependent M6P reductase, NADPH-dependent mannose 6-phosphate reductase, NADPH-mannose-6-P reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.224 mannose-6-phosphate 6-reductase

Cloned

Cloned on EC 1.1.1.224 - mannose-6-phosphate 6-reductase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
; single gene, constitutive, DNA sequence determination and analysis, expression in Escherichia coli
-
expression in Arabidopsis thaliana
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expression in transgenic Arabidopsis thaliana plants, the transformed plants show reduced salt injury, less inhibition of vegetative growth, and increased seed production, thus increased salt tolerance, relative to the wild-type plants. When treated with 200 mM NaCl, transformants produce no seeds, but do bolt, and exhibit less chlorosis/necrosis and greater survival and dry weights than the wild-type. Without salt there are no M6PR effects on growth or phenotype, but expression levels of 2272 genes are altered, e.g upregulation of ABA receptor genes, PYL4, PYL5, and PYL6, and downregulation of protein phosphatase 2C genes, ABI1 and ABI2, overview
transgenic tomato plants bearing a gene construct containing a specific 277-bp fragment from M6PR-mRNA, in an inverted-repeat configuration. Eight independent lines containing the M6PR-silencing inverted-repeat construct pBin-IR-M6PR construct are regenerated
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