EC Number   |
Protein Variants |
Reference |
|---|
   4.6.1.23 | C148S |
point mutation constructed from cDNA clone |
646312 |
| 4.6.1.23 | C6S |
point mutation constructed from cDNA clone |
646312 |
| 4.6.1.23 | E125I |
site-directed mutagenesis |
730369 |
| 4.6.1.23 | E96A |
mutagenised using the T7-GEN TM in vitro mutagenesis kit, 80% less cytotoxity to HeLa cells |
-, 646304 |
| 4.6.1.23 | E96Q |
mutagenesis variant protein |
-, 646311 |
| 4.6.1.23 | H137Q |
a variant which is completely devoid of cytotoxicity and ribonucleolytic activity, retains the wildtype native conformation |
-, 704754 |
| 4.6.1.23 | H137Q |
mutagenesis variant protein |
-, 646311 |
| 4.6.1.23 | H137Q |
similar to the wild-type and mutant R121Q, this mutant is cytotoxic in HeLa cells or Cos-7 cells in a dose-dependent manner. Both GFP and luciferase expression are not inhibited |
707861 |
| 4.6.1.23 | H137Q |
substitution abolishes the catalytic activity |
-, 646304 |
| 4.6.1.23 | H50/137Q |
mutagenesis variant protein |
-, 646311 |
