EC Number   |
Protein Variants |
Reference |
|---|
   4.2.3.6 | C146A |
complete loss of activity |
648336 |
| 4.2.3.6 | C190A |
significantly reduced enzymatic activity |
648336 |
| 4.2.3.6 | D100E |
crystal structure |
648350 |
| 4.2.3.6 | D100E |
mutant generates anomalous sesquiterpenes, proportion of anomalous products increases if enzyme is incubated in presence of Mn2+ |
648348 |
| 4.2.3.6 | D100E |
mutant with different binding of diphosphate |
664108 |
| 4.2.3.6 | D101E |
Km-value for farneyl diphosphate: 124 nM |
648347 |
| 4.2.3.6 | D101E |
mutant generates anomalous sesquiterpenes, proportion of anomalous products increases if enzyme is incubated in presence of Mn2+ |
648348 |
| 4.2.3.6 | D102E |
mutation in substrate binding domain, mutant generates anomalous sesquiterpenes |
648345 |
| 4.2.3.6 | D104E |
mutant generates anomalous sesquiterpenes, proportion of anomalous products increases if enzyme is incubated in presence of Mn2+ |
648348 |
| 4.2.3.6 | D109E |
the mutant with increased activity shows more stability than the wild type enzyme, an increased number of electrostatic interactions and better binding energies with the ligand |
748247 |
