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EC Number
Protein Variants
Commentary
Reference
3.4.24.85
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M19 mutant cell line of CHO-K1 cells with no s2p activity
644079
3.4.24.85
more
mutants in any of the histidines for phenylalanine or glutamic acid for alanine of the consensus metal-binding site abolished activity
644079
3.4.24.85
D467N
mutation of aspartate abolish activity suggesting that is the third residue that coordinates the zinc active site of S2P
644080
3.4.24.85
N337Q
mutation at glycosylation site N337 does not abolish activity
644080
3.4.24.85
N508Q
mutation does not abolish activity
644080
3.4.24.85
D402N
abolished activity
644083
3.4.24.85
E23Q
abolished activity
644083
3.4.24.85
H22F
abolished activity
644083
3.4.24.85
H26F
abolished activity
644083
3.4.24.85
D148A
mutant exhibits markedly compromised protease activity
682860
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