Literature summary for 3.4.24.85 extracted from

Feng, L.; Yan, H.; Wu, Z.; Yan, N.; Wang, Z.; Jeffrey, P.D.; Shi, Y.
Structure of a site-2 protease family intramembrane metalloprotease (2007), Science, 318, 1608-1612.

Search for more literature for 3.4.24.85

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Methanocaldococcus jannaschii

Protein Variants

Protein Variants	Comment	Organism
D148A	mutant exhibits markedly compromised protease activity	Methanocaldococcus jannaschii
E55A	mutant exhibits markedly compromised protease activity	Methanocaldococcus jannaschii
H54A	mutant exhibits markedly compromised protease activity	Methanocaldococcus jannaschii
H54A/D148A	mutant exhibits markedly compromised protease activity	Methanocaldococcus jannaschii
H58A	mutant exhibits markedly compromised protease activity	Methanocaldococcus jannaschii

Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	1,10-phenanthroline specifically inhibits substrate cleavage in a concentration-dependent manner	Methanocaldococcus jannaschii

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	dependent	Methanocaldococcus jannaschii

Organism

Organism	UniProt	Comment	Textmining
Methanocaldococcus jannaschii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SREBP NH2-522 fragment + H2O	-	Methanocaldococcus jannaschii	NH2-484 fragment + 38 aa fragment	-	?

Synonyms

Synonyms	Comment	Organism
S2P	-	Methanocaldococcus jannaschii
site-2 protease	-	Methanocaldococcus jannaschii

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Release 2026.1 (March 2026)