EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.38 | C25S |
inactive |
732561 |
| 3.4.22.38 | G243E |
the missense mutation is associated with autosomal recessive pycnodysostosis |
709409 |
| 3.4.22.38 | K9E |
the mutant shows decreased catalytic efficiencies towards Z-Leu-Arg-7-amido-4-methylcoumarin and Z-Gly-Pro-Arg-7-amido-4-methylcoumarin compared to the wild type enzyme |
717867 |
| 3.4.22.38 | K9E/I171E/Q172S |
the mutant shows decreased catalytic efficiency towards Z-Leu-Arg-7-amido-4-methylcoumarin and increased catalytic efficiency towards Z-Gly-Pro-Arg-7-amido-4-methylcoumarin compared to the wild type enzyme |
717867 |
| 3.4.22.38 | K9E/I171E/Q172S/N190M/K191G/L195K |
the mutant shows decreased catalytic efficiency towards Z-Leu-Arg-7-amido-4-methylcoumarin and increased catalytic efficiency towards Z-Gly-Pro-Arg-7-amido-4-methylcoumarin compared to the wild type enzyme |
717867 |
| 3.4.22.38 | K9E/N190M/K191G/L195K |
the mutant shows increased catalytic efficiency towards Z-Leu-Arg-7-amido-4-methylcoumarin and decreased catalytic efficiency towards Z-Gly-Pro-Arg-7-amido-4-methylcoumarin compared to the wild type enzyme |
717867 |
| 3.4.22.38 | more |
10-week-old male cathepsin K-deficient knockout mice show bones that are mechanically more brittle, while both osteoclasts and osteoblasts show impaired activity relative to the wild type, phenotype with significant hypercalcification of the calcified cartilage and cortices, overview |
-, 697066 |
| 3.4.22.38 | more |
bone marrow transplantation for selective disruption of CatK in the haematopoietic system, usage of total bone marrow progenitor cells from CatK-/-, CatK-/+, and CatK+/+, and low-density lipoprotein receptor knockout mice. Silencing of leucocyte CatK results in phenotypic changes in bone formation with an increased total bone mineral density in the CatK2/2 chimeras, effect of leucocyte cathepsin K deficiency on bone remodelling, overview |
697150 |
| 3.4.22.38 | more |
catK-deficient cells show a similar suppression of actin rings as wild-type osteoclasts treated with inhibitor LHVS |
-, 698935 |
| 3.4.22.38 | more |
construction of male and female wild-type, heterozygous, and homozygous CatK null mice, phenotypes in young mice, bone mass, strength, resorption, and formation, overview. CatK-/- mice show higher bone mineral density at the central and distal femur. Central femur ultimate load is positively influenced by genotype, and is positively correlated with both cortical area and bone mineral content. Lumbar vertebral body ultimate load is also positively correlated to bone mineral content. Genotype does not influence the relationship of ultimate load to bone mineral content in either the central femur or vertebral body |
697011 |
