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Literature summary for 3.4.22.38 extracted from

  • Pennypacker, B.; Shea, M.; Liu, Q.; Masarachia, P.; Saftig, P.; Rodan, S.; Rodan, G.; Kimmel, D.
    Bone density, strength, and formation in adult cathepsin K (-/-) mice (2009), Bone, 44, 199-207.
    View publication on PubMed
Search for more literature for 3.4.22.38

Protein Variants

Protein Variants Comment Organism
additional information construction of male and female wild-type, heterozygous, and homozygous CatK null mice, phenotypes in young mice, bone mass, strength, resorption, and formation, overview. CatK-/- mice show higher bone mineral density at the central and distal femur. Central femur ultimate load is positively influenced by genotype, and is positively correlated with both cortical area and bone mineral content. Lumbar vertebral body ultimate load is also positively correlated to bone mineral content. Genotype does not influence the relationship of ultimate load to bone mineral content in either the central femur or vertebral body Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
carboxybenzoyl-Phe-Phe-CHN2
-
 Mus musculus
E-64
-
 Mus musculus
leupeptin
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Mus musculus CatK is a cysteine protease expressed predominantly in osteoclastsosteoclasts, that plays a prominent role in degrading type I collagen. Growing CatK null mice have osteopetrosis associated with a reduced ability to degrade bone matrix ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
-
osteoclast CatK expressed predominantly in osteoclasts Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O
-
 Mus musculus ?
-
 ?
collagen I + H2O CatK is a cysteine protease expressed predominantly in osteoclastsosteoclasts, that plays a prominent role in degrading type I collagen. Growing CatK null mice have osteopetrosis associated with a reduced ability to degrade bone matrix Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
catK
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 CatK is a lysosomal cysteine protease that degrades type I collagen at neutral and acidic pH Mus musculus