EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.37 | C244A |
mature enzyme numbering, inactive, correct localization |
687373 |
| 3.4.22.37 | DELTA435-507 |
largely inactive, incorrect localization in culture supernatant and periplasm |
687373 |
| 3.4.22.37 | more |
4 naturally occuring enzyme deficient mutants: rgpA-deficient mutant shows 77% activity compared to the wild-type activity with type I collagen, while a rgpB-deficent mutant shows 82% activity, and a double-deficient mutant strain shows only 6% activity, another mutant lacking the to arginine-specific isozyme and the lysine-specific gingipain KGP shows 5% remaining activity |
-, 651379 |
| 3.4.22.37 | more |
construction of a strain producing Kgp proteinase without the adhesin domains in a Rgp/Kgp/adhesin-null mutant, mutant strains 33277, KDP133, and KDP137 phenotypes, overview |
-, 699480 |
| 3.4.22.37 | more |
construction of enzyme-deficient mutants KDP136 with DELTArgpADELTArgpBDELTAkgp, and KDP133 with DELTAkgp. The mutants do not, in contrast to the wild-type enzyme, inhibit cellular proliferation and don not arrest the cell cycle in the G0/G1 phase as well as decrease the expression levels of the cell-cycle regulatory molecules cyclin D and cyclin E in murine ST2 cells, overview |
-, 700531 |
| 3.4.22.37 | more |
gingipain-deficient Porphyromonas gingivalis mutants lacking both Arg- and Lys-gingipains are unable to induce interleukin-1beta, interleukin-6, and interleukin-8 degradation |
700534 |
| 3.4.22.37 | more |
mutant RgpA-deficient isogenic strain W501 and RgpB-deficient isogenic strain D7 show 50% of wild-type strain W50 enzyme activity |
668922 |
| 3.4.22.37 | more |
Rgp null mutant strain KDP133 shows platelet aggregation similar to the wild-type strain ATCC 33277, while neither the Rgp/Kgp null mutant strain, nor the adhesin null mutant strain show platelet aggregation |
670317 |
| 3.4.22.37 | more |
strain W501 is deficient for RgpA, strain E8 for Rgp, and strain D7 for RgpB |
667475 |
