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Literature summary for 3.4.22.37 extracted from

  • Seers, C.A.; Slakeski, N.; Veith, P.D.; Nikolof, T.; Chen, Y.Y.; Dashper, S.G.; Reynolds, E.C.
    The RgpB C-terminal domain has a role in attachment of RgpB to the outer membrane and belongs to a novel C-terminal-domain family found in Porphyromonas gingivalis (2006), J. Bacteriol., 188, 6376-6386.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Cloned(Commentary)

Cloned (Comment) Organism
RgpB as a full-length zymogen, with a catalytic Cys244Ala mutation, or with the C-terminal 72 amino acids deleted in an Arg-gingipain Porphyromonas gingivalis mutant (YH522AB) and an Arg- and Lys-gingipain mutant (YH522KAB) Porphyromonas gingivalis

Protein Variants

Protein Variants Comment Organism
C244A mature enzyme numbering, inactive, correct localization Porphyromonas gingivalis
DELTA435-507 largely inactive, incorrect localization in culture supernatant and periplasm Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane outer membrane attached Porphyromonas gingivalis 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
 x * 56000, RgpB, calculated from the deduced amino acid sequence Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis important virulence factors in periodontitis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
 strains ATCC 53978 (W50) and ATCC 33277
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information important virulence factors in periodontitis Porphyromonas gingivalis ?
-
 ?
N-alpha-benzoyl-L-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-alpha-benzoyl-L-arginine + 4-nitroaniline
-
 ?

Subunits

Subunits Comment Organism
? native and C244A mutant enzyme expressed with numerous bands, 80000-9000 Da, SDS-PAGE Porphyromonas gingivalis
? truncated enzyme expressed as 71000 Da and 48000 Da isoforms, SDS-PAGE Porphyromonas gingivalis
? x * 56000, RgpB, calculated from the deduced amino acid sequence Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis