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Literature summary for 3.4.22.37 extracted from

  • Rangarajan, M.; Hashim, A.; Aduse-Opoku, J.; Paramonov, N.; Hounsell, E.F.; Curtis, M.A.
    Expression of Arg-gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50 (2005), Infect. Immun., 73, 4864-4878.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information mutant RgpA-deficient isogenic strain W501 and RgpB-deficient isogenic strain D7 show 50% of wild-type strain W50 enzyme activity Porphyromonas gingivalis

General Stability

General Stability Organism
expression of RgpB is required for correct glycosylation and stability of monomeric RgpA from strain W50 Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
genes rgpA and rgpB, wild-type strain W50, RgpA-deficient isogenic strain W501, and RgpB-deficient isogenic strain D7
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein monosaccharide composition of RgpA, expression of RgpB is required for correct glycosylation and stability of monomeric RgpA from strain W50 Porphyromonas gingivalis

Purification (Commentary)

Purification (Comment) Organism
native enzymes by ammonium sulfate fractionation, ion exchange and affinity chromatography, RgpA and RgpB by different methods, overview Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha-benzoyl-D,L-Arg-4-nitroanilide + H2O
-
Porphyromonas gingivalis Nalpha-benzoyl-D,L-Arg + 4-nitroaniline
-
?
Nalpha-benzoyl-L-Arg-4-nitroanilide + H2O
-
Porphyromonas gingivalis Nalpha-benzoyl-L-Arg + 4-nitroaniline
-
?

Subunits

Subunits Comment Organism
dimer heterodimeric RgpA fused to adhesin, i.e. HRgpA Porphyromonas gingivalis
monomer RgpA Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
Porphyromonas gingivalis
RgpA
-
Porphyromonas gingivalis
RgpB
-
Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
assay at Porphyromonas gingivalis

pH Stability

pH Stability pH Stability Maximum Comment Organism
7.8 8.3 stability of RgpA catalytic domain of wild-type and D7 mutant strain at 30°C in absence or presence of 2-mercaptoethanol or Ca2+, overview Porphyromonas gingivalis