EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.B7 | more |
generation of a MASP-1 catalytic fragment encoding the CCP1-CCP2-SP region (rMASPcf) |
732519 |
| 3.4.21.B7 | more |
generation of a MASP-1-deficient mouse model |
731099 |
| 3.4.21.B7 | more |
generation of a truncated enzyme version comprising the MAPS-1 CUB1-EGF-CUB2 domains, i.e. MASP-1 D1-3 CBD, rapid dissociation upon EDTA treatment, and heterodimer formation, exchange of subunits between dimers in the presence of Ca2+, overview. Heterodimer formation between N-terminal fragemnts of MASP1 and MASP-2, i.e. MASP-1 D1-3 and MASP-2 D1-3, is structurally allowed but takes place to only a small amount |
732518 |
| 3.4.21.B7 | more |
MASP-1 ent, catalytically active form of MASP-1 produced by substituting residues 425Lys-His-Ile-Ser-Arg |
659350 |
| 3.4.21.B7 | R448Q |
site-directed mutagenesis |
732519 |
| 3.4.21.B7 | R504Q |
site-directed mutagenesis, construction of a MASP-1 catalytic fragment, that has a molecular weight of 45.5 kDa and consists of the three C-terminal domains complement control protein 1 and 2 followed by the serine protease domain |
732693 |
| 3.4.21.B7 | S627A |
kinetic parameters similiar to wild type, mutant is activated by its active counterpart |
669707 |
| 3.4.21.B7 | S646A |
site-directed mutagenesis |
732519 |
| 3.4.21.B7 | S646A |
site-directed mutagenesis, the mutant remains as inactive zymogen |
732869 |
