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Literature summary for 3.4.21.B7 extracted from

  • Sekine, H.; Takahashi, M.; Iwaki, D.; Fujita, T.
    The role of MASP-1/3 in complement activation (2013), Adv. Exp. Med. Biol., 735, 41-53.
    View publication on PubMed
Search for more literature for 3.4.21.B7

Protein Variants

Protein Variants Comment Organism
additional information generation of a MASP-1-deficient mouse model Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor D zymogen + H2O Mus musculus
-
 mature factor D + ?
-
 ?
MASP-2 zymogen + H2O Mus musculus MASP-2 is a key enzyme that cleaves C4 and C2 to assemble a C3 convertase mature MASP-2 + ?
-
 ?
MASP-3 zymogen + H2O Mus musculus
-
 mature MASP-3 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P98064
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor D zymogen + H2O
-
 Mus musculus mature factor D + ?
-
 ?
MASP-2 zymogen + H2O
-
 Mus musculus mature MASP-2 + ?
-
 ?
MASP-2 zymogen + H2O MASP-2 is a key enzyme that cleaves C4 and C2 to assemble a C3 convertase Mus musculus mature MASP-2 + ?
-
 ?
MASP-3 zymogen + H2O
-
 Mus musculus mature MASP-3 + ?
-
 ?

Synonyms

Synonyms Comment Organism
MASP-1
-
 Mus musculus
MBL-associated serine protease
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice lack alternative pathway activation because factor D remains as a proenzyme in the serum Mus musculus
physiological function MASP-1 and MASP-3 seem to be involved in activation of both the lectin and alternative complement system pathways Mus musculus