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Literature summary for 3.4.21.B7 extracted from

  • Hess, K.; Ajjan, R.; Phoenix, F.; Dobo, J.; Gal, P.; Schroeder, V.
    Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation (2012), PLoS ONE, 7, e35690.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B7

Protein Variants

Protein Variants Comment Organism
R504Q site-directed mutagenesis, construction of a MASP-1 catalytic fragment, that has a molecular weight of 45.5 kDa and consists of the three C-terminal domains complement control protein 1 and 2 followed by the serine protease domain Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C2 + H2O Homo sapiens
-
 ?
-
 ?
fibrinogen + H2O Homo sapiens MASP-1-induced fibrin formation and activation is thrombin-dependent, in plasma environment fibrin formation is not directly induced by MASP-1 in the absence of prothrombin fibrin + ?
-
 ?
proform factor XIII + H2O Homo sapiens activation mature factor XIII + ?
-
 ?
proform thrombin-activatable fibrinolysis inhibitor + H2O Homo sapiens activation mature thrombin-activatable fibrinolysis inhibitor + ?
-
 ?
prothrombin + H2O Homo sapiens activation thrombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P48740
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C2 + H2O
-
 Homo sapiens ?
-
 ?
fibrinogen + H2O low activity Homo sapiens fibrin + ?
-
 ?
fibrinogen + H2O MASP-1-induced fibrin formation and activation is thrombin-dependent, in plasma environment fibrin formation is not directly induced by MASP-1 in the absence of prothrombin Homo sapiens fibrin + ?
-
 ?
additional information no activity with complement component C4. Direct activation of C3 convertase by MASP-1 occurs with very low catalytic efficiency and is not of physiological relevance Homo sapiens ?
-
 ?
proform factor XIII + H2O activation Homo sapiens mature factor XIII + ?
-
 ?
proform factor XIII + H2O the Val34 variant is a better substrate than the Leu34 variant Homo sapiens mature factor XIII + ?
-
 ?
proform thrombin-activatable fibrinolysis inhibitor + H2O
-
 Homo sapiens mature thrombin-activatable fibrinolysis inhibitor + ?
-
 ?
proform thrombin-activatable fibrinolysis inhibitor + H2O activation Homo sapiens mature thrombin-activatable fibrinolysis inhibitor + ?
-
 ?
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?
prothrombin + H2O activation Homo sapiens thrombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
MASP-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
 mutant R504Q catalytic fragment, the mutant is resistant to autolysis and preserves its enzymatic activity during prolonged incubation, estimated half-life of several hours in plasma at 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function MASP-1 cleaves complement component C2 but not complement component C4 and therefore is not capable of generating C3 convertase alone Homo sapiens