EC Number   |
Protein Variants |
Reference  |
|---|
   3.4.21.93 | more |
construction of an PC3 containing a 19 amino-acid transmembrane sequence, and/or a C-terminal glycosylation tag, the C-terminal extension is exposed to the endoplasmic reticulum lumen, overview |
667660 |
| 3.4.21.93 | more |
PC1/3 null mutant mice show C-terminally impaired but not completely blocked proIAPP processing, overview |
668377 |
| 3.4.21.93 | more |
construction of PC1 prosegment, amino acids 1-110, fused to the C-terminal PC1 tail, amino acids 619-753, termed proCT construct |
668621 |
| 3.4.21.93 | more |
PC1/3-deficient cells do not show preproGIP processing |
669436 |
| 3.4.21.93 | D65A |
site-directed mutagenesis of the propeptide residue, leads to reduced inhibition of mature PC1 by the separated propeptide mutant compared to the wild-type propeptide |
669518 |
| 3.4.21.93 | D66A |
site-directed mutagenesis of the propeptide residue, leads to reduced inhibition of mature PC1 by the separated propeptide mutant compared to the wild-type propeptide |
669518 |
| 3.4.21.93 | D67A |
site-directed mutagenesis of the propeptide residue, leads to increased inhibition of mature PC1 by the separated propeptide mutant compared to the wild-type propeptide |
669518 |
| 3.4.21.93 | K61A |
site-directed mutagenesis of the propeptide residue, leads to reduced inhibition of mature PC1 by the separated propeptide mutant compared to the wild-type propeptide |
669518 |
| 3.4.21.93 | more |
single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme |
669518 |
| 3.4.21.93 | R50A |
site-directed mutagenesis of the propeptide residue, leads to increased inhibition of mature PC1 by the separated propeptide mutant compared to the wild-type propeptide |
669518 |
