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Literature summary for 3.4.21.93 extracted from

  • Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
    Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor (2006), J. Biol. Chem., 281, 11050-11057.
    View publication on PubMed
Search for more literature for 3.4.21.93

Protein Variants

Protein Variants Comment Organism
additional information PC1/3-deficient cells do not show preproGIP processing Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucose-dependent insulinotropic polypeptide precursor + H2O Mus musculus PC1/3 is essential for pro-GIP processing glucose-dependent insulinotropic polypeptide + propeptide of glucose-dependent insulinotropic polypeptide GIP ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alpha-TC1.9 cell pancreatic alpha-cell line, low expression level Mus musculus
-
AtT-20 cell pituitary gland cell line Mus musculus
-
intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucose-dependent insulinotropic polypeptide precursor + H2O PC1/3 is essential for pro-GIP processing Mus musculus glucose-dependent insulinotropic polypeptide + propeptide of glucose-dependent insulinotropic polypeptide GIP ?
glucose-dependent insulinotropic polypeptide precursor + H2O i.e. pro-GIP, incretin hormone Mus musculus glucose-dependent insulinotropic polypeptide + propeptide of glucose-dependent insulinotropic polypeptide GIP ?

Synonyms

Synonyms Comment Organism
PC1/3
-
 Mus musculus
prohormone convertase 1/3
-
 Mus musculus