Cloned (Comment) | Organism |
---|---|
co-expression of PC1/3 and rat pro-islet amyloid polypeptide, proIAPP, in GH3 cells lacking the enzyme, leads to cleavage of recombinant proIAPP | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | PC1/3 null mutant mice show C-terminally impaired but not completely blocked proIAPP processing, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-islet amyloid polypeptide + H2O | Mus musculus | precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the C- and N-terminus | islet amyloid polypeptide + pro-peptides of islet amyloid polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-islet amyloid polypeptide + H2O | precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the C- and N-terminus | Mus musculus | islet amyloid polypeptide + pro-peptides of islet amyloid polypeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC1/3 | - |
Mus musculus |
prohormone convertase 1/3 | - |
Mus musculus |