EC Number   |
Protein Variants |
Reference |
|---|
   3.1.3.67 | L42R |
activity is comparable with or even higher than that of wild-type enzyme |
650767 |
| 3.1.3.67 | S10N |
activity is comparable with or even higher than that of wild-type enzyme |
650767 |
| 3.1.3.67 | T401I |
activity is comparable with or even higher than that of wild-type enzyme |
650767 |
| 3.1.3.67 | V369G |
activity is comparable with or even higher than that of wild-type enzyme |
650767 |
| 3.1.3.67 | C124S |
adenovirus encoding a dominant negative human PTEN cDNA is used for the transduction of cell cultures |
692556 |
| 3.1.3.67 | more |
adipose tissue-specific depletion of PTEN in mice results in improved glucose tolerance and insulin sensitivity rendering mice resistant to streptozotocin-induced diabetes. Increased recruitment of Glut4 transporters at the plasma membrane of adipocytes,whereas the contrary is observed in muscle of the same animals. Decreased expression of resistin is shown |
677869 |
| 3.1.3.67 | more |
CA1 synapses in hippocampal slices from PTEN-deficient mice exhibit activity-induced long-term potentiation of synaptic transmission but are resistant to long-term depression. PTEN reduces phosphatidylinositol-3-kinase activity and pharmacological inhibition of phosphatidylinositol-3-kinase restores long-term depression of synaptic transmission in PTEN-deficient mice, suggesting that inhibition of phosphatidylinositol-3-kinase is necessary for induction of long term depression |
682123 |
| 3.1.3.67 | C124S |
catalytically inactive mutant enzyme |
650763 |
| 3.1.3.67 | C124S |
catalytically inert mutant enzyme |
653626 |
| 3.1.3.67 | D92A |
catalytically inert mutant enzyme, retains partial ability to induce cells to accumulate in G1 |
653626 |
