Application | Comment | Organism |
---|---|---|
medicine | results demonstrate an important role of PTEN in long term depression and suggest that alterations in PTEN can have an impact on learning and memory process | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | CA1 synapses in hippocampal slices from PTEN-deficient mice exhibit activity-induced long-term potentiation of synaptic transmission but are resistant to long-term depression. PTEN reduces phosphatidylinositol-3-kinase activity and pharmacological inhibition of phosphatidylinositol-3-kinase restores long-term depression of synaptic transmission in PTEN-deficient mice, suggesting that inhibition of phosphatidylinositol-3-kinase is necessary for induction of long term depression | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
PTEN | - |
Mus musculus |