Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A121P | inactive mutant enzyme | Homo sapiens |
C105F | inactive mutant enzyme | Homo sapiens |
C124R | inactive mutant enzyme | Homo sapiens |
C136Y | inactive mutant enzyme | Homo sapiens |
C71Y | inactive mutant enzyme | Homo sapiens |
D107Y | inactive mutant enzyme | Homo sapiens |
D331G | mutant enzyme with partial activity | Homo sapiens |
F342N | mutant enzyme with partial activity | Homo sapiens |
F347L | mutant enzyme with partial activity | Homo sapiens |
G129E | inactive mutant enzyme | Homo sapiens |
G129R | inactive mutant enzyme | Homo sapiens |
G165R | inactive mutant enzyme | Homo sapiens |
G20E | mutant enzyme with partial activity | Homo sapiens |
G251C | inactive mutant enzyme | Homo sapiens |
H61R | inactive mutant enzyme | Homo sapiens |
H93Y | inactive mutant enzyme | Homo sapiens |
K289E | mutant enzyme with partial activity | Homo sapiens |
L112P | inactive mutant enzyme | Homo sapiens |
L112R | inactive mutant enzyme | Homo sapiens |
L345Q | inactive mutant enzyme | Homo sapiens |
L42R | activity is comparable with or even higher than that of wild-type enzyme | Homo sapiens |
M134L | mutant enzyme with partial activity | Homo sapiens |
R130G | inactive mutant enzyme | Homo sapiens |
R130L | inactive mutant enzyme | Homo sapiens |
R130Q | inactive mutant enzyme | Homo sapiens |
R173C | inactive mutant enzyme | Homo sapiens |
R173H | inactive mutant enzyme | Homo sapiens |
R173P | inactive mutant enzyme | Homo sapiens |
S10N | activity is comparable with or even higher than that of wild-type enzyme | Homo sapiens |
S170N | inactive mutant enzyme | Homo sapiens |
S170R | inactive mutant enzyme | Homo sapiens |
S227F | mutant enzyme with partial activity | Homo sapiens |
T401I | activity is comparable with or even higher than that of wild-type enzyme | Homo sapiens |
V133I | inactive mutant enzyme | Homo sapiens |
V343E | inactive mutant enzyme | Homo sapiens |
V369G | activity is comparable with or even higher than that of wild-type enzyme | Homo sapiens |
Y155C | inactive mutant enzyme | Homo sapiens |
Y16C | inactive mutant enzyme | Homo sapiens |
Y174N | inactive mutant enzyme | Homo sapiens |
Y27S | inactive mutant enzyme | Homo sapiens |
Y68H | inactive mutant enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol-3,4,5-trisphosphate + H2O | Homo sapiens | lipid phosphatase activity of PTEN is critical for its tumor suppressor function and the enzyme negatively regulates the phosphatidylinositol 3'-kinase-protein kinase B pathway | phosphatidylinositol-4,5-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Homo sapiens | inositol 1,4,5-trisphosphate + phosphate | - |
? | |
phosphatidylinositol 3,4,5-trisphosphate + H2O | - |
Homo sapiens | phosphatidyl inositol 4,5-bisphosphate + phosphate | - |
? | |
phosphatidylinositol-3,4,5-trisphosphate + H2O | lipid phosphatase activity of PTEN is critical for its tumor suppressor function and the enzyme negatively regulates the phosphatidylinositol 3'-kinase-protein kinase B pathway | Homo sapiens | phosphatidylinositol-4,5-bisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PTEN | - |
Homo sapiens |