EC Number   |
Protein Variants |
Reference |
|---|
   3.1.1.8 | A184V |
naturally occuring mutation in exon 2 |
694563 |
| 3.1.1.8 | A199S/F227A/S287G/A328W/E441D |
the mutant has significantly lower kcat and KM values against acetylcholine than the wild type enzyme |
716278 |
| 3.1.1.8 | A199S/F227A/S287G/A328W/Y332G/E441D |
the mutant has significantly lower kcat and KM values against acetylcholine than the wild type enzyme |
716278 |
| 3.1.1.8 | A199S/S287G/A328W/Y332G |
the mutant has significantly lower kcat and KM values against acetylcholine than the wild type enzyme |
716278 |
| 3.1.1.8 | A277W |
mutation does not affect binding of E2020 |
651163 |
| 3.1.1.8 | A328C |
the mutation leads to hysteresis with butyrylthiocholine |
729273 |
| 3.1.1.8 | A328F |
altered Ki for E2020 |
651163 |
| 3.1.1.8 | A328F |
mutant enzyme retains activity at pH 5 under conditions of excess substrate similar to the wild-type enzyme |
651156 |
| 3.1.1.8 | A328F |
no substrate activation |
650347 |
| 3.1.1.8 | A328F |
the mutant is more sensitive to aryl phenothiazine carbamate inhibitors and deactivation, i.e. 4-biphenyl phenothiazine carbamate, compared to the wild-type enzyme |
693553 |
