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(+/-)-cocaine + H2O
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Substrates: -
Products: -
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(-)-cocaine + H2O
ecgonine methyl ester + benzoate
Substrates: -
Products: -
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(R)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
-
Substrates: -
Products: -
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(R)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
-
Substrates: -
Products: -
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(S)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
-
Substrates: -
Products: -
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(S)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
-
Substrates: -
Products: -
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(S)-butyrylthiocholine + H2O
thiocholine + butyrate
2,2,2-trifluoro-N-(2-nitrophenyl)acetamide + H2O
2-nitroaniline + trifluoroacetate
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Substrates: a neutral amide
Products: -
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2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
-
Substrates: -
Products: -
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2,6-dichlorophenolindophenyl acetate + H2O
?
-
Substrates: -
Products: -
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2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
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Substrates: good substrate
Products: -
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2,6-dichlorophenolindophenylacetate + H2O
?
-
Substrates: -
Products: -
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2-nitroacetanilide + H2O
2-nitroaniline + acetate
-
Substrates: a neutral amide
Products: -
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2-nitrophenyl butyrate
2-nitrophenol + butyrate
-
Substrates: -
Products: -
?
2-trimethylsilyl-ethyl-N-n-butylcarbamate + H2O
?
-
Substrates: -
Products: -
?
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
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Substrates: weak substrate
Products: -
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3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
-
Substrates: -
Products: -
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3,3-dimethylbutyl-N-n-butylcarbamate + H2O
?
-
Substrates: -
Products: -
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3-(acetamido) N,N,N-trimethylanilinium + H2O
3-amino-N,N,N-trimethylanilinium + acetate
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Substrates: a positively charged amide, hydrolysis by the wild-type enzyme and the mutant D70G shows a long transient phase preceeding the steady state, hysteretic burst induction phase, overview
Products: -
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3-(acetamido)N,N,N-trimethylanilinium + H2O
?
-
Substrates: -
Products: -
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3-nitroacetanilide + H2O
3-nitroaniline + acetate
-
Substrates: a neutral amide
Products: -
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6-monoacetylmorphine + H2O
morphine + acetate
Substrates: -
Products: -
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7-ethyl-10-[4-(1-piperidine)-1-piperidino]carbonyloxycamtothecin + H2O
7-ethyl-10-hydroxycamptothecin + ?
Substrates: anticancer drug irinotecan CPT-11
Products: -
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acetoacetylcholine + H2O
acetoacetate + choline
-
Substrates: -
Products: -
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acetyl choline + H2O
acetate + choline
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Substrates: enzyme also acts on acetyl choline to a lesser extent
Products: -
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acetyl-beta-methylcholine
beta-methylcholine + acetate
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
acetyl-beta-methylcholine + H2O
methylcholine + acetate
-
Substrates: -
Products: -
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acetyl-beta-methylthiocholine + H2O
acetate + beta-methylthiocholine
-
Substrates: -
Products: -
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acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
acetylcholine + H2O
acetate + choline
acetylcholine + H2O
choline + acetate
acetylcholine iodide + H2O
choline iodide + acetate
-
Substrates: -
Products: -
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acetylsalicylic acid + H2O
acetate + salicylate
Substrates: -
Products: -
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acetylthiocholine + H2O
?
-
Substrates: detection with 5,5-dithiobis(2-nitrobenzoic acid)
Products: -
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acetylthiocholine + H2O
acetate + thiocholine
acetylthiocholine + H2O
thiocholine + acetate
acetylthiocholine iodide + H2O
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
acetylthiocholine iodide + H2O
thiocholine + acetate
-
Substrates: -
Products: -
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acetylthiocholine iodide + H2O
thiocholine iodide + acetate
-
Substrates: -
Products: -
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adipyldicholine + H2O
adipic acid + choline
Substrates: lower activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry,
Products: -
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BChE-FP + H2O
?
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Substrates: structure-based design and application of a fluorogenic molecular probe, BChE-FP, specific to butyrylcholinesterase (BChE). This compound is rationally designed by mimicking the native substrate and optimized stepwise by manipulating the steric feature and the reactivity of the designed probe targeting the structural difference of the active pockets of BChE and acetylcholinesterase (AChE). The refined probe, BChE-FP, exhibits high specificity toward BChE compared to AChE, producing about 275fold greater fluorescence enhancement upon the catalysis by BChE, molecular docking simulation, overview. The proximity of Ser198 to the carbonyl group of BChE-FP is about 4.3 A in the BChE active site, whereas the proximity of Ser203 to the carbonyl group of BChE-FP is about 7.4 A in the AChE active site. The binding affinity of BChE-FP with BChE is B100fold greater than that of acetylthiocholine, while the catalytic constant for BChE-FP is 190fold lower than that of acetylthiocholine
Products: -
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benzoylcholine + H2O
benzoate + choline
benzoylcholine + H2O
benzoic acid + choline
Substrates: -
Products: -
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benzoylcholine + H2O
choline + benzoate
benzoylthiocholine + H2O
?
-
Substrates: -
Products: -
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benzoylthiocholine + H2O
thiocholine + benzoate
beta-hydroxybutyrylcholine + H2O
3-hydroxybutanoate + choline
-
Substrates: -
Products: -
?
butyryl choline + H2O
butyrate + choline
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Substrates: preferred substrate
Products: -
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butyrylcholine + H2O
butanoate + choline
butyrylcholine + H2O
butyrate + choline
butyrylcholine + H2O
choline + butyrate
butyrylcholine iodide + H2O
?
-
Substrates: -
Products: -
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butyrylthiocholine + H2O
?
butyrylthiocholine + H2O
butanoate + thiocholine
butyrylthiocholine + H2O
butyrate + thiocholine
butyrylthiocholine + H2O
thiocholine + butyrate
butyrylthiocholine chloride + H2O
?
-
Substrates: -
Products: -
?
butyrylthiocholine iodide + H2O
?
-
Substrates: -
Products: -
?
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
butyrylthiocholine iodide + H2O
thiocholine + butyrate
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
butyrylthiocholinium chloride + H2O
?
-
Substrates: -
Products: -
?
bytyrylhiocholine + H2O
thiocholine + butyrate
-
Substrates: -
Products: -
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cocaine + H2O
ecgonine methyl ester + benzoate
crotonylcholine + H2O
crotonate + choline
-
Substrates: -
Products: -
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D-butyryl-alpha-methylcholine + H2O
butanoate + alpha-methylcholine
D-butyryl-beta-methylcholine + H2O
butanoate + beta-methylcholine
echothiophate + H2O
?
Substrates: substrate for mutant enzyme G117H
Products: -
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ethyl ([2-[bis(propan-2-yl)amino]ethyl]-sulfanyl)(methyl)phosphinate + H2O
?
Substrates: substrate for mutant enzyme G117H
Products: -
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ethyl n-butyrate + H2O
ethanol + n-butanoate
formylthiocholine + H2O
thiocholine + formate
Substrates: via formation of the tetrahedral intermediate, measurement of heavy atom kinetic isotope effects
Products: -
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heroin + H2O
6-monoacetylmorphine + acetate
Substrates: -
Products: -
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heroin + H2O
?
Substrates: -
Products: -
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indophenyl acetate + H2O
?
-
Substrates: -
Products: -
?
indophenylacetate + H2O
?
-
Substrates: -
Products: -
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indophenylacetate + H2O
indophenol + acetate
-
Substrates: -
Products: -
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isoamyl isovalerate + H2O
isopentanol + isopentanoate
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