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Synonyms
cholinesterase, butyrylcholinesterase, buche, plasma cholinesterase, serum cholinesterase, pseudocholinesterase, choline esterase, hubche, hbche, plasma esterase,
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an acylcholine + H2O = choline + a carboxylate
an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
mechanism
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an acylcholine + H2O = choline + a carboxylate
enzyme is able to stabilize covalent tetrahedral intermediate adduct with substrate
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an acylcholine + H2O = choline + a carboxylate
molecular dynamics simulation in aqueous solution, nucleophilic S198 and the various binding subsites in the catalytic cavitiy are readily accessible from the exterior of the protein, the catalytic triad E325/H438/S198 is stablized by presence of a sodium ion
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an acylcholine + H2O = choline + a carboxylate
the catalytic residue is Ser198
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an acylcholine + H2O = choline + a carboxylate
the enzyme follows a mechanism similar to that of a serine protease in which the activated serine attacks the acyl-substrate to form an acyl-enzyme intermediate. The acyl-enzyme intermediate then reacts directly with a water molecule at the active site. Both the acylation and deacylation reactions occur through a tetrahedral intermediate
an acylcholine + H2O = choline + a carboxylate
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(+/-)-cocaine + H2O
?
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?
(-)-cocaine + H2O
ecgonine methyl ester + benzoate
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?
(R)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
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-
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?
(R)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
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?
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
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?
(S)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
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?
(S)-butyrylthiocholine + H2O
thiocholine + butyrate
2,2,2-trifluoro-N-(2-nitrophenyl)acetamide + H2O
2-nitroaniline + trifluoroacetate
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a neutral amide
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?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
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?
2,6-dichlorophenolindophenyl acetate + H2O
?
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?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
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good substrate
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?
2,6-dichlorophenolindophenylacetate + H2O
?
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?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
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a neutral amide
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?
2-nitrophenyl butyrate
2-nitrophenol + butyrate
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?
2-trimethylsilyl-ethyl-N-n-butylcarbamate + H2O
?
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?
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
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weak substrate
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?
3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
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?
3,3-dimethylbutyl-N-n-butylcarbamate + H2O
?
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?
3-(acetamido) N,N,N-trimethylanilinium + H2O
3-amino-N,N,N-trimethylanilinium + acetate
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a positively charged amide, hydrolysis by the wild-type enzyme and the mutant D70G shows a long transient phase preceeding the steady state, hysteretic burst induction phase, overview
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?
3-(acetamido)N,N,N-trimethylanilinium + H2O
?
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?
3-nitroacetanilide + H2O
3-nitroaniline + acetate
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a neutral amide
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?
6-monoacetylmorphine + H2O
morphine + acetate
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-
-
?
7-ethyl-10-[4-(1-piperidine)-1-piperidino]carbonyloxycamtothecin + H2O
7-ethyl-10-hydroxycamptothecin + ?
anticancer drug irinotecan CPT-11
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?
acetoacetylcholine + H2O
acetoacetate + choline
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-
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?
acetyl choline + H2O
acetate + choline
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enzyme also acts on acetyl choline to a lesser extent
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?
acetyl-beta-methylcholine
beta-methylcholine + acetate
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
acetyl-beta-methylcholine + H2O
methylcholine + acetate
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-
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?
acetyl-beta-methylthiocholine + H2O
acetate + beta-methylthiocholine
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?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
acetylcholine + H2O
acetate + choline
acetylcholine + H2O
choline + acetate
acetylcholine iodide + H2O
choline iodide + acetate
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?
acetylsalicylic acid + H2O
acetate + salicylate
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?
acetylthiocholine + H2O
?
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detection with 5,5-dithiobis(2-nitrobenzoic acid)
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?
acetylthiocholine + H2O
acetate + thiocholine
acetylthiocholine + H2O
thiocholine + acetate
acetylthiocholine iodide + H2O
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
acetylthiocholine iodide + H2O
thiocholine + acetate
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-
-
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?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
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?
adipyldicholine + H2O
adipic acid + choline
lower activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry,
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?
BChE-FP + H2O
?
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structure-based design and application of a fluorogenic molecular probe, BChE-FP, specific to butyrylcholinesterase (BChE). This compound is rationally designed by mimicking the native substrate and optimized stepwise by manipulating the steric feature and the reactivity of the designed probe targeting the structural difference of the active pockets of BChE and acetylcholinesterase (AChE). The refined probe, BChE-FP, exhibits high specificity toward BChE compared to AChE, producing about 275fold greater fluorescence enhancement upon the catalysis by BChE, molecular docking simulation, overview. The proximity of Ser198 to the carbonyl group of BChE-FP is about 4.3 A in the BChE active site, whereas the proximity of Ser203 to the carbonyl group of BChE-FP is about 7.4 A in the AChE active site. The binding affinity of BChE-FP with BChE is B100fold greater than that of acetylthiocholine, while the catalytic constant for BChE-FP is 190fold lower than that of acetylthiocholine
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?
benzoylcholine + H2O
benzoate + choline
benzoylcholine + H2O
benzoic acid + choline
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?
benzoylcholine + H2O
choline + benzoate
benzoylthiocholine + H2O
?
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?
benzoylthiocholine + H2O
thiocholine + benzoate
beta-hydroxybutyrylcholine + H2O
3-hydroxybutanoate + choline
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?
butyryl choline + H2O
butyrate + choline
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preferred substrate
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?
butyrylcholine + H2O
butanoate + choline
butyrylcholine + H2O
butyrate + choline
butyrylcholine + H2O
choline + butyrate
butyrylcholine iodide + H2O
?
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?
butyrylthiocholine + H2O
?
butyrylthiocholine + H2O
butanoate + thiocholine
butyrylthiocholine + H2O
butyrate + thiocholine
butyrylthiocholine + H2O
thiocholine + butyrate
butyrylthiocholine chloride + H2O
?
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?
butyrylthiocholine iodide + H2O
?
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?
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
butyrylthiocholine iodide + H2O
thiocholine + butyrate
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
butyrylthiocholinium chloride + H2O
?
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-
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?
bytyrylhiocholine + H2O
thiocholine + butyrate
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?
cocaine + H2O
ecgonine methyl ester + benzoate
crotonylcholine + H2O
crotonate + choline
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?
D-butyryl-alpha-methylcholine + H2O
butanoate + alpha-methylcholine
D-butyryl-beta-methylcholine + H2O
butanoate + beta-methylcholine
3.1.1.8 cholinesterase
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