EC Number   |
Protein Variants |
Reference |
|---|
    2.7.1.21 | A167Y |
heavily reduced ability to phosphorylate pyrimidine nucleosides, ability to phosphorylate ganciclovir and lobucavir is reduced 2fold |
641160 |
| 2.7.1.21 | A175V |
site-sirected mutagenesis, inactive mutant, mutation of residue 51 might in vivo be involved into generation of acyclovir resistance of HSV |
660722 |
| 2.7.1.21 | C336Y |
acyclovir resistant, mutation affects ATP binding site |
641167 |
| 2.7.1.21 | D77N |
site-sirected mutagenesis, mutant activity is slightly increased compared to the wild-type enzyme |
660722 |
| 2.7.1.21 | E83K |
site-sirected mutagenesis, inactive mutant, mutation of residue 51 might in vivo be involved into generation of acyclovir resistance of HSV |
660722 |
| 2.7.1.21 | G294A |
site-directed mutagenesis, about 80% reduced activity compared to the wild-type enzyme, no activity with TTP as cofactor |
661194 |
| 2.7.1.21 | G294V |
site-directed mutagenesis, nearly inactive mutant, no ATP binding |
661194 |
| 2.7.1.21 | H121N |
similar subunit structure to wild-type enzyme, decreased enzyme activity |
641150 |
| 2.7.1.21 | H121N |
the mutant has less than 7% kinase activity compared to the wild type enzyme |
723301 |
| 2.7.1.21 | H13I |
the mutant shows strongly increased Km compared to the wild type enzyme |
705803 |
