EC Number   |
Protein Variants |
Reference |
|---|
    2.7.1.1 | A188E |
kinetic mutation effects are increased S0.5, decreased Hill number, decreased kcat, decreased Km for ATP |
703968 |
| 2.7.1.1 | A188W |
kinetic mutation effects are increased S0.5, decreased kcat, decreased Km for ATP |
703968 |
| 2.7.1.1 | A208G |
mutant displays a slightly higher glucose affinity and similar ATP affinity to the wild type enzyme. The activity of the enzyme at 5 mM glucose is moderately higher than the wild type activity |
677004 |
| 2.7.1.1 | A208W |
kinetic mutation effects are increased S0.5, decreased kcat, decreased Hill number, increased Km for ATP |
703968 |
| 2.7.1.1 | A378V |
kinetic mutation effects are increased S0.5, increased Km for ATP |
703968 |
| 2.7.1.1 | A379S |
mutation isolated in a type 2 diabetes patient |
738711 |
| 2.7.1.1 | A379T |
kcat(1/sec): 61.2, D-glucose S05 (mM): 12.3, Km (ATP): 0.87 mM, relative inhibition of glucokinase activity through GKRP alone: 17% and GKRP plus 10 microM sorbitol 6-phosphate: 53% |
721533 |
| 2.7.1.1 | A379V |
mutations is associated with mature-onset diabetes of the young, type 2 (MODY2). Vmax is 65% of maximal activity, Km-value for ATP is 1.5fold higher than wild-type enzyme |
688144 |
| 2.7.1.1 | A456V |
activating glucokinase mutation |
703274 |
| 2.7.1.1 | A456V |
inactivating mutation in glucokinase causing hyperinsulinemic hypoglycemia subtype glucokinase |
703968 |
