EC Number   |
Protein Variants |
Reference  |
|---|
    1.14.14.17 | L393F |
terbinafine-resistant strains/patient isolates all contain this missense point mutation responsible for the resistance to the drug |
657561 |
| 1.14.14.17 | L398F |
site-directed mutagenesis, introduction of the mutation equivalent to L393F found in terbinafine-resistant Trichophyton rubrum strains, mutation renders Saccharomyces cerevisiae strain INVSc1 expressing the recombinant Candida albicans enzyme insensitive to terbafine |
657561 |
| 1.14.14.17 | D407F |
site-directed mutagenesis, mutant shows 8% of wild-type activity |
657764 |
| 1.14.14.17 | K399F |
site-directed mutagenesis, mutant shows 28% of wild-type activity |
657764 |
| 1.14.14.17 | K399F/R400F/D407F |
site-directed mutagenesis, triple mutant shows 10% of wild-type activity |
657764 |
| 1.14.14.17 | K399P/R400P/D407P |
site-directed mutagenesis, triple mutant shows 10% of wild-type activity |
657764 |
| 1.14.14.17 | K399W/R400W/D407W |
site-directed mutagenesis, inactive mutant |
657764 |
| 1.14.14.17 | more |
construction of a truncated enzyme mutant |
657764 |
| 1.14.14.17 | R400F |
site-directed mutagenesis, mutant shows 24% of wild-type activity |
657764 |
| 1.14.14.17 | more |
construction of a disruption mutant of both gene ERG1 alleles, which is lethal, and of a heterozygous ERG1 disruptant mutant by disruption of one ERG1 allele, while the second is controlled by the regulable promotor MET3p repressable by methionine and cysteine, the heterozyygous mutant strain does not produce ergosterol, conditional mutant shows reduced passive diffusion of drug into the cells, hyphal morphogenesis is affected in the mutant, overview |
658999 |
