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Literature summary for 1.14.14.17 extracted from

  • Osborne, C.S.; Leitner, I.; Favre, B.; Ryder, N.S.
    Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine (2005), Antimicrob. Agents Chemother., 49, 2840-2844.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis of terbinafine-resistant strains/patient isolates Trichophyton rubrum
expression of mutant L398F in Saccharomyces cerevisiae strain INVSc1 Candida albicans

Protein Variants

Protein Variants Comment Organism
L393F terbinafine-resistant strains/patient isolates all contain this missense point mutation responsible for the resistance to the drug Trichophyton rubrum
L398F site-directed mutagenesis, introduction of the mutation equivalent to L393F found in terbinafine-resistant Trichophyton rubrum strains, mutation renders Saccharomyces cerevisiae strain INVSc1 expressing the recombinant Candida albicans enzyme insensitive to terbafine Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
terbinafine sensitive strains, residue Leu398 is responsible for the inhibitory effect, mutant L398F is insensitive Candida albicans
terbinafine sensitive strains, residue Leu393 is responsible for the inhibitory effect Trichophyton rubrum

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Trichophyton rubrum
-
-

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Trichophyton rubrum
-
 dermatophyte, 6 sequential isolates from 1 patient, resistant to terbinafine
-

Synonyms

Synonyms Comment Organism
SE
-
 Candida albicans
SE
-
 Trichophyton rubrum
squalene epoxidase
-
 Candida albicans
squalene epoxidase
-
 Trichophyton rubrum