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Information on EC 1.14.14.17 - squalene monooxygenase

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IUBMB Comments
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, SE, SE1, SE3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
squalene + [reduced NADPH-hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
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