EC Number   |
Protein Variants |
Reference |
|---|
    1.14.14.154 | C37L/C442A |
site-directed mutagenesis, structure determination |
-, 684486 |
| 1.14.14.154 | D116E |
the azole Kd value of the mutant enzyme is little altered compared to the wild type enzyme |
-, 726803 |
| 1.14.14.154 | D134G |
the mutation significantly impacts azole sensitivity |
726714 |
| 1.14.14.154 | E113D |
increase in sensitivity to fluconazole, voriconazole, no difference in sensitivity to itraconazole |
657522 |
| 1.14.14.154 | F105L |
the azole Kd value of the mutant enzyme is little altered compared to the wild type enzyme |
-, 726803 |
| 1.14.14.154 | F145A |
the mutation leads to a serious weakening of steroid ligand binding |
727052 |
| 1.14.14.154 | F145L |
significant modification of heme environment as judged from spectral properties, about 45% of wild-type activity, resistant to azoles |
659097 |
| 1.14.14.154 | F180L |
the naturally occuring mutation is responsible for the resistance to triazoles |
671942 |
| 1.14.14.154 | G143A |
a cytochrome b substitution mutation |
689083 |
| 1.14.14.154 | G484S |
azole resistance |
701738 |
