Literature summary for 1.14.14.154 extracted from

Fraaije, B.A.; Cools, H.J.; Kim, S.; Motteram, J.; Clark, W.S.; Lucas, J.A.
A novel substitution 1381V in the sterol 14alpha-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides (2007), Mol. Plant Pathol., 8, 245-254.

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Protein Variants

Protein Variants	Comment	Organism
G143A	a cytochrome b substitution mutation	Zymoseptoria tritici
I381V	naturally occuring mutation, the mutant shows reduced sensitivity to azole inhibitors	Zymoseptoria tritici
additional information	construction of a deletion mutant by deletion of codons 459 and 460, the mutant shows a continuous distribution of EC50 values across isolates with either I381 or V381, and has no measurable effect on azole sensitivity	Zymoseptoria tritici

Inhibitors

Inhibitors	Comment	Organism	Structure
azoxystrobin	-	Zymoseptoria tritici
difenoconazole	an azole inhibitor	Zymoseptoria tritici
additional information	EC50 values, structure-function relationship of enzyme and inhibitor interactions, overview	Zymoseptoria tritici
tebuconazole	an azole inhibitor	Zymoseptoria tritici

Organism

Organism	UniProt	Comment	Textmining
Zymoseptoria tritici	-	-	-

Synonyms

Synonyms	Comment	Organism
CYP51	-	Zymoseptoria tritici
sterol 14alpha-demethylase	-	Zymoseptoria tritici

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Release 2023.1 (January 2023)