show all | hide all No of entries

Information on EC 1.14.14.154 - sterol 14alpha-demethylase

for references in articles please use BRENDA:EC1.14.14.154
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This heme-thiolate (P-450) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses two successive hydroxylations of the 14alpha-methyl group, followed by elimination as formate, leaving a 14(15) double bond.
Specify your search results
Select one or more organisms in this record:
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cyp51, erg11, cyp51a, cyp51a1, erg11p, lanosterol 14alpha-demethylase, lanosterol 14 alpha-demethylase, lanosterol demethylase, cyp51b, cacyp51, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 14alpha-formylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a DELTA14-steroid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1c)
-
-
-
a 14alpha-hydroxymethylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-formylsteroid + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
(1b)
-
-
-
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
show the reaction diagram
a 14alpha-methylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-hydroxymethylsteroid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
-
-
-