EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.112 | M990A |
fails to generate St-2 |
687607 |
| 3.4.21.112 | M990I |
fails to generate St-2 |
687607 |
| 3.4.21.112 | M990L |
fails to generate St-2 |
687607 |
| 3.4.21.112 | more |
cartilage-specific S1P knockout mice, exhibit chondrodysplasia and a complete lack of endochondral ossification even though Runx2 expression, Indian hedgehog signaling, and osteoblastogenesis is intact. Substantial increase in chondrocyte apoptosis. Collagen network is disorganized and collagen becomes entrapped in chondrocytes. Endoplasmic reticulum in chondrocytes is engorged and fragmented in a manner characteristic of severe endoplasmic reticulum stress |
687906 |
| 3.4.21.112 | more |
complete silencing of SKI-1/SP1 results in an embryonic lethal phenotype, elimination of about 70-90% of SKI-1/SP1 protein expression in liver results in a drop of ca. 50% in the level of circulating cholesterol and triglycerides, cholesterol and fatty acid biosynthesis in hepatocytes declines by 75%, low density lipoprotein receptor mRNA declines by 50% |
673908 |
| 3.4.21.112 | more |
Crimean Congo hemorrhagic fever virus-infected cells deficient in SKI-1/S1P produce no infectious virus, although precursor Gn and precursor Gc accumulate normally in the Golgi apparatus, the site of virus assembly. Complementation of SKI-1/S1P-deficient cells with a SKI-1/S1P expression vector restores release of infectious virus |
688727 |
| 3.4.21.112 | more |
in a ypdC null mutant, induction of sigmaW-controlled genes is abolished and site-1 proteolysis of RsiW is completely blocked. Defect of sigmaW induction is complemented by ectopically integrated ypdC under xylose control in a heterologous Escherichia coli system |
689039 |
| 3.4.21.112 | more |
in the triple shedding site mutant KLL/A autocatalytic generation of St-1 is abrogated, St-2 fragment is generated at a level of ca. 15% |
687607 |
| 3.4.21.112 | more |
prsW insertion/deletion mutant prsW::erm exacerbates the growth defect of an sdpI mutant |
-, 686949 |
| 3.4.21.112 | more |
S1P-deficient cells, ATF6 processing partially blocked |
675939 |
