Literature summary for 3.4.21.112 extracted from

Patra, D.; Xing, X.; Davies, S.; Bryan, J.; Franz, C.; Hunziker, E.B.; Sandell, L.J.
Site-1 protease is essential for endochondral bone formation in mice (2007), J. Cell Biol., 179, 687-700.

Search for more literature for 3.4.21.112

Application

Application	Comment	Organism
medicine	S1P plays an integral role in skeletal development. S1P activity is necessary for a specialized endoplasmic reticulum stress response required by chondrocytes for the genesis of normal cartilage and thus endochondral ossification	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	cartilage-specific S1P knockout mice, exhibit chondrodysplasia and a complete lack of endochondral ossification even though Runx2 expression, Indian hedgehog signaling, and osteoblastogenesis is intact. Substantial increase in chondrocyte apoptosis. Collagen network is disorganized and collagen becomes entrapped in chondrocytes. Endoplasmic reticulum in chondrocytes is engorged and fragmented in a manner characteristic of severe endoplasmic reticulum stress	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrocyte	S1P is abundantly expressed in the chondrocytes in the developing wild-type forelimb at all stages	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
S1P	-	Mus musculus

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Release 2023.1 (January 2023)