EC Number   |
Protein Variants |
Reference |
|---|
   3.4.17.23 | R697G |
deleterious missense variant |
762786 |
| 3.4.17.23 | S19P |
deleterious missense variant |
762786 |
| 3.4.17.23 | S547C |
deleterious missense variant |
762786 |
| 3.4.17.23 | S692P |
deleterious missense variant |
762786 |
| 3.4.17.23 | more |
generation of triple-transgenic-model mice with brain ACE2 overexpression on a chronically hypertensive, AngII-increased background. The transgenic mice show dramatically decreased baseline spontaneous baroreflex sensitivity and brain ACE2 activity compared with nontransgenic mice, whereas peripheral ACE2 activity/expression remains unaffected |
708683 |
| 3.4.17.23 | more |
M2-mutant CHO cells, mutated in tumor necrosis factor alpha-converting enzyme, TACE, show reduced shedding of the ectodomain of ACE2 and increased release of the larger soluble enzyme form, compared to the smaller one, overview. Tandem mutation in the juxtamembrane region also causes a decreaee in the small soluble enzyme form |
707055 |
| 3.4.17.23 | G211R |
missense variant, mutation affect protein structure and stability |
762786 |
| 3.4.17.23 | K26R |
missense variant, mutation affect protein structure and stability |
762786 |
| 3.4.17.23 | N720D |
missense variant, mutation affect protein structure and stability |
762786 |
| 3.4.17.23 | E484K |
mutation forms high-affinity complexes (~40% more than wild-type) |
763365 |
