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Literature summary for 3.4.17.23 extracted from

  • Iwata, M.; Silva Enciso, J.E.; Greenberg, B.H.
    Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme (2009), Am. J. Physiol. Cell Physiol., 297, C1318-C1329.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells Cricetulus griseus
expression in E4 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information M2-mutant CHO cells, mutated in tumor necrosis factor alpha-converting enzyme, TACE, show reduced shedding of the ectodomain of ACE2 and increased release of the larger soluble enzyme form, compared to the smaller one, overview. Tandem mutation in the juxtamembrane region also causes a decreaee in the small soluble enzyme form Cricetulus griseus

Inhibitors

Inhibitors Comment Organism Structure
N-[(1S)-1-carboxy-3-methylbutyl]-3-(3,5-dichlorophenyl)-L-histidine i.e. C16, a ACE2 specific inhibitor Cricetulus griseus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding Mus musculus 16020
-
membrane the larger form of ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding resulting in the smaller soluble enzyme form Cricetulus griseus 16020
-
soluble smaller enzyme form without ectodomain Cricetulus griseus
-
-

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the lager membraneous and smaller soluble enzyme forms are glycosylated Cricetulus griseus

Source Tissue

Source Tissue Comment Organism Textmining
additional information no activity in CHO cell Cricetulus griseus
-
additional information no activity in EC cells Mus musculus
-

Subunits

Subunits Comment Organism
More ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding involving tumor necrosis factor alpha-converting enzyme, TACE Mus musculus
More ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding resulting in the smaller soluble enzyme form and involving tumor necrosis factor alpha-converting enzyme, TACE, mechanism, overview Cricetulus griseus

Synonyms

Synonyms Comment Organism
ACE2
-
Cricetulus griseus
ACE2
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Cricetulus griseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Cricetulus griseus

General Information

General Information Comment Organism
physiological function ACE2 is a regulator of the renin-angiotensin system Cricetulus griseus
physiological function ACE2 is a regulator of the renin-angiotensin system Mus musculus