Cloned (Comment) | Organism |
---|---|
expression in CHO cells | Cricetulus griseus |
expression in E4 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | M2-mutant CHO cells, mutated in tumor necrosis factor alpha-converting enzyme, TACE, show reduced shedding of the ectodomain of ACE2 and increased release of the larger soluble enzyme form, compared to the smaller one, overview. Tandem mutation in the juxtamembrane region also causes a decreaee in the small soluble enzyme form | Cricetulus griseus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[(1S)-1-carboxy-3-methylbutyl]-3-(3,5-dichlorophenyl)-L-histidine | i.e. C16, a ACE2 specific inhibitor | Cricetulus griseus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding | Mus musculus | 16020 | - |
membrane | the larger form of ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding resulting in the smaller soluble enzyme form | Cricetulus griseus | 16020 | - |
soluble | smaller enzyme form without ectodomain | Cricetulus griseus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the lager membraneous and smaller soluble enzyme forms are glycosylated | Cricetulus griseus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | no activity in CHO cell | Cricetulus griseus | - |
additional information | no activity in EC cells | Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
More | ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding involving tumor necrosis factor alpha-converting enzyme, TACE | Mus musculus |
More | ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding resulting in the smaller soluble enzyme form and involving tumor necrosis factor alpha-converting enzyme, TACE, mechanism, overview | Cricetulus griseus |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Cricetulus griseus |
ACE2 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cricetulus griseus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Cricetulus griseus |
General Information | Comment | Organism |
---|---|---|
physiological function | ACE2 is a regulator of the renin-angiotensin system | Cricetulus griseus |
physiological function | ACE2 is a regulator of the renin-angiotensin system | Mus musculus |