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EC Number Protein Variants Commentary Reference
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145V84M site-directed mutagenesis, altered substrate specificity and kinetics, and highly reduced activity compared to the wild-type enzyme 661583
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145V84S site-directed mutagenesis, altered substrate specificity and kinetics, and reduced activity compared to the wild-type enzyme 661583
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145V84S/M88R/A110D site-directed mutagenesis, altered substrate specificity and kinetics, and highly reduced activity compared to the wild-type enzyme 661583
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145Y70W mutant enzyme loses activity towards purines. Negative cooperativity towards dThd and dCyd is observed 673584
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