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Information on EC 2.7.1.145 - deoxynucleoside kinase
for references in articles please use BRENDA:EC2.7.1.145
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EC Tree 2 Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.145 deoxynucleoside kinase
IUBMB Comments
The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2′-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2′-deoxyribonucleosides.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 2.7.1.145
- thymidine
- drosophila
- deoxycytidine
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suicide
- deoxyguanosine
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herpes
- medicine
- deoxyadenosine
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e-5-2-bromovinyl-2'-deoxyuridine
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kinase-deficient
- dttp
- deoxythymidine
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dado
- 1-beta-d-arabinofuranosylthymine
- synthesis
- agriculture
Reaction Schemes
showSynonyms
dm-dnk, deoxyribonucleoside kinase, deoxynucleoside kinase, multisubstrate deoxyribonucleoside kinase, pyrimidine deoxyribonucleoside kinase, dmdnk, deoxyribonucleoside phosphotransferase, multi-substrate deoxyribonucleoside kinase, xen-pyk, d. melanogaster deoxynucleoside kinase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D. melanogaster deoxynucleoside kinase
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deoxyribonucleoside kinase
deoxyribonucleoside kinase
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deoxyribonucleoside phosphotransferase
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Dm-dNK
DmdNK
dNK
kinase (phosphorylating), deoxynucleoside
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ms-dNK
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multifunctional deoxynucleoside kinase
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multispecific deoxynucleoside kinase
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multisubstrate deoxyribonucleoside kinase
nucleoside triphosphate: deoxyribonucleoside 5'-phosphotransferase
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additional information
Dm-dNK
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dNK
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dNK
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dNK
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multisubstrate deoxyribonucleoside kinase
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multisubstrate deoxyribonucleoside kinase
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additional information
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the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
additional information
the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
additional information
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the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
additional information
the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
additional information
the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
additional information
the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
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ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
compulsory ordered steady-state reaction mechanism with formation of a ternary complex with the phosphate donor and acceptor
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ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
the enzyme from embryonic cells of Drosophila melanogaster differs from other deoxynucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common deoxynucleosides
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ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
positive cooperativity mechanism, substrate and nucleotide interactions and binding sites, overview
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ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
straight forward hyperbolic kinetic reaction mechanism following a compulsory ordered steady-state reaction mechanism with formation of a ternary complex, substrate interactions
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
substrate binding and interactions
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
compulsory ordered steady-state reaction mechanism with formation of a ternary complex with the phosphate donor and acceptor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
purine deoxyribonucleosides salvage, pyrimidine deoxyribonucleosides salvage
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SYSTEMATIC NAME
IUBMB Comments
ATP:deoxynucleoside 5'-phosphotransferase
The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.
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CAS REGISTRY NUMBER
COMMENTARY
52227-81-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(E)-5-(2-bromovinyl)-2'-deoxyuridine + ATP
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate + ADP
1-beta-D-arabinofuranosylcytosine + ATP
1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP
1-beta-D-arabinofuranosylthymine + ATP
1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP
2',3'-didehydro-3'-deoxythymidine + ATP
2',3'-didehydro-3'-deoxythymidine 5'-phosphate + ADP
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Substrates: -
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?
2',3'-dideoxythymidine + ATP
2',3'-dideoxythymidine 5'-phosphate + ADP
Substrates: 4.44% of the activity with thymidine
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?
2'-deoxy-2'-fluoroadenosine 3'-triphosphate + 2'-deoxyadenosine
2'-deoxy-2'-fluoroadenosine 3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
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Substrates: low activity
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?
2'-deoxycytidine + CTP
2'-deoxycytidine 5'-phosphate + CDP
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Substrates: -
Products: -
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?
3'-fluoro-2',3'-dideoxythymidine + ATP
3'-fluoro-2',3'-dideoxythymidine 5'-phosphate + ADP
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Substrates: 0.03% of the activity with thymidine and 2'-deoxycytidine
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adenosine-2'-deoxy-2'-fluoro-3'-triphosphate + 2'-deoxycytidine
adenosine-2'-deoxy-2'-fluoro-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
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Substrates: low activity
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adenosine-2'-deoxy-3'-triphosphate + 2'-deoxyadenosine
adenosine-2'-deoxy-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
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Substrates: low activity
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?
adenosine-2'-deoxy-3'-triphosphate + 2'-deoxycytidine
adenosine-2'-deoxy-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
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Substrates: low activity
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adenosine-3'-deoxy-2'-triphosphate + 2'-deoxyadenosine
adenosine-3'-deoxy-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
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Substrates: low activity
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adenosine-3'-deoxy-2'-triphosphate + 2'-deoxycytidine
adenosine-3'-deoxy-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
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Substrates: low activity
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adenosine-3'-deoxy-3'-fluoro-2'-triphosphate + 2'-deoxycytidine
adenosine-3'-deoxy-3'-fluoro-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
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Substrates: low activity
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ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
Substrates: high activity
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?
ATP + 1-(beta-D-arabinofuranosyl)-cytosine
ADP + 1-(beta-D-arabinofuranosyl)-cytosine 5'-phosphate
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Substrates: -
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?
ATP + 1-(beta-D-arabinofuranosyl)-thymine
ADP + 1-(beta-D-arabinofuranosyl)-thymine 5'-phosphate
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Substrates: -
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ATP + 1-beta-D-arabinofuranosylcytosine
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
ATP + 1-beta-D-arabinofuranosylguanine
ADP + 1-beta-D-arabinofuranosylguanine 5'-phosphate
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Substrates: poor substrate for the wild-type enzyme but moderate activity with N-terminally truncated mutants M88R and V84A/M88R
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ATP + 1-beta-D-arabinofuranosylthymine
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
ATP + 2',2'-difluorodeoxyguanosine
ADP + 2',2'-difluorodeoxyguanosine 5'-phosphate
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Substrates: poor substrate for the wild-type enzyme but moderate activity with N-terminally truncated mutants M88R and V84A/M88R
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ATP + 2',3'-didehydro-3'-deoxythymidine
ADP + 2',3'-didehydro-3'-deoxythymidine 5'-phosphate
ATP + 2'-deoxy-2',2'-difluorocytidine
ADP + difluorodeoxycytidine 5'-phosphate
Substrates: 2'-deoxy-2',2'-difluorocytidine is gemcitabine, dNK is an activator of gemcitabine
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ATP + 2'-deoxyinosine
ADP + 2'-deoxyinosine 5'-phosphate
Substrates: -
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ATP + 2-amino-8-(1'-beta-D-2'-deoxyribofuranosyl)-imidazo[1,2-a]-1,3,5-triazin-4(8H)-one
ADP + 2-amino-8-(1'-beta-D-2'-deoxyribofuranosyl)-imidazo[1,2-a]-1,3,5-triazin-4(8H)-one 5'-phosphate
Substrates: -
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?
ATP + 2-chlorodeoxyadenosine
ADP + 2-chlorodeoxyadenosine 5'-phosphate
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Substrates: -
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ATP + 2-hydroxy-2'-deoxyadenosine
ADP + 2-hydroxy-2'-deoxyadenosine 5'-monophosphate
Substrates: preferred substrate for enzyme mutant 4
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ATP + 3'-azido-2',3'-didehydro-3'-deoxythymidine
ADP + 3'-azido-2',3'-didehydro-3'-deoxythymidine 5'-phosphate
ATP + 3'-deoxyadenosine
ADP + 3'-deoxyadenosine 5'-phosphate
Substrates: -
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ATP + 5-(E)-(2-bromvinyl)-2'-deoxyuridine
ADP + 5-(E)-(2-bromvinyl)-2'-deoxyuridine 5'-phosphate
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Substrates: -
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ATP + 6-amino-5-nitro-3-(1'-beta-D-2'-deoxyribofuranosyl)-2(1H)-pyridone
ADP + 6-amino-5-nitro-3-(1'-beta-D-2'-deoxyribofuranosyl)-2(1H)-pyridone 5'-phosphate
Substrates: -
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ATP + 9-beta-D-arabinofuranosyladenine
ADP + 9-beta-D-arabinofuranosyladenine 5'-phosphate
ATP + adenosine
ADP + adenosine 5'-phosphate
Substrates: low activity
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?
ATP + arabinosyl-2-fluoroadenine
ADP + arabinosyl-2-fluoroadenine 5'-monophosphate
Substrates: -
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?
ATP + arabinosyladenine
ADP + arabinosyladenine 5'-monophosphate
Substrates: -
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ATP + arabinosyluridine
ADP + arabinosyluridine 5'-monophosphate
Substrates: -
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ATP + dideoxycytidine
ADP + dideoxycytidine 5'-phosphate
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Substrates: wild-type enzyme: low activity
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ATP + E-5-(2-bromovinyl)-2'-deoxyuridine
ADP + E-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
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Substrates: -
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ATP + E-5-(2-bromovinyl)-2'-deoxyuridine
ADP + E-5-(2-bromovinyl)-2'-deoxyuridine phosphate
ATP + ganciclovir
ADP + ganciclovir phosphate
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Substrates: poor substrate for the wild-type enzyme but moderate activity with N-terminally truncated mutants M88R and V84A/M88R
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ATP + guanosine
ADP + guanosine 5'-phosphate
Substrates: low activity
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ATP + inosine
ADP + inosine 5'-phosphate
Substrates: very low activity
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?
bromovinyldeoxyuridine + ATP
bromovinyldeoxyuridine 5'-phosphate + ADP
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Substrates: specificity constant 930 per s and M
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difluorodeoxycytidine + ATP
difluorodeoxycytidine 5'-phosphate + ADP
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Substrates: i.e. gemcitabine. Efficient in vivo phosphorylation, specificity constant 4800 per s and M
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?
thymidine + CTP
thymidine 5'-phosphate + CDP
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Substrates: -
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(E)-5-(2-bromovinyl)-2'-deoxyuridine + ATP
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate + ADP
-
Substrates: -
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(E)-5-(2-bromovinyl)-2'-deoxyuridine + ATP
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate + ADP
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Substrates: 54% of the activity with thymidine
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(E)-5-(2-bromovinyl)-2'-deoxyuridine + ATP
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate + ADP
Substrates: 54% of the activity with thymidine
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1-beta-D-arabinofuranosylcytosine + ATP
1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP
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Substrates: 10% of the activity with thymidine and 2'-deoxycytidine
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1-beta-D-arabinofuranosylcytosine + ATP
1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP
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Substrates: 58.2% of the activity with thymidine
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1-beta-D-arabinofuranosylcytosine + ATP
1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP
Substrates: 58.2% of the activity with thymidine
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1-beta-D-arabinofuranosylcytosine + ATP
1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP
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Substrates: 50% of the activity with thymidine and 2'-deoxycytidine
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1-beta-D-arabinofuranosylthymine + ATP
1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP
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Substrates: 15% of the activity with thymidine and 2'-deoxycytidine
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1-beta-D-arabinofuranosylthymine + ATP
1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP
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Substrates: 53.9% of the activity with thymidine
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1-beta-D-arabinofuranosylthymine + ATP
1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP
Substrates: 53.9% of the activity with thymidine
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2',3'-dideoxyadenosine + ATP
2',3'-dideoxyadenosine 5'-phosphate + ADP
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Substrates: 0.9% of the activity with thymidine
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2',3'-dideoxyadenosine + ATP
2',3'-dideoxyadenosine 5'-phosphate + ADP
Substrates: 0.9% of the activity with thymidine
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?
2',3'-dideoxycytidine + ATP
2',3'-dideoxycytidine 5'-phosphate + ADP
-
Substrates: -
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?
2',3'-dideoxycytidine + ATP
2',3'-dideoxycytidine 5'-phosphate + ADP
Substrates: 11.1% of the activity with thymidine
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2',3'-dideoxycytidine + ATP
2',3'-dideoxycytidine 5'-phosphate + ADP
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Substrates: 0.02% of the activity with thymidine and 2'-deoxycytidine
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2'-deoxyadenosine + ATP
2'-deoxyadenosine 5'-phosphate + ADP
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Substrates: specificity constant 33000 per s and M
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2'-deoxyadenosine + ATP
2'-deoxyadenosine 5'-phosphate + ADP
-
Substrates: -
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2'-deoxyadenosine + ATP
2'-deoxyadenosine 5'-phosphate + ADP
Substrates: 96% of the activity with thymidine
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2'-deoxyadenosine + ATP
2'-deoxyadenosine 5'-phosphate + ADP
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Substrates: 5% of the activity with thymidine and 2'-deoxycytidine
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2'-deoxyadenosine + ATP
2'-deoxyadenosine 5'-phosphate + ADP
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Substrates: 15% of the activity with thymidine and 2'-deoxycytidine
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2'-deoxycytidine + ATP
2'-deoxycytidine 5'-phosphate + ADP
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Substrates: specificity constant 18000 per s and M
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2'-deoxycytidine + ATP
2'-deoxycytidine 5'-phosphate + ADP
-
Substrates: -
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2'-deoxycytidine + ATP
2'-deoxycytidine 5'-phosphate + ADP
Substrates: -
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2'-deoxycytidine + ATP
2'-deoxycytidine 5'-phosphate + ADP
Substrates: 134% of the activity with thymidine
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2'-deoxycytidine + ATP
2'-deoxycytidine 5'-phosphate + ADP
-
Substrates: -
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2'-deoxyguanosine + ATP
2'-deoxyguanosine 5'-phosphate + ADP
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Substrates: specificity constant 10000 per s and M
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2'-deoxyguanosine + ATP
2'-deoxyguanosine 5'-phosphate + ADP
-
Substrates: -
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2'-deoxyguanosine + ATP
2'-deoxyguanosine 5'-phosphate + ADP
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Substrates: 1% of the activity with thymidine and 2'-deoxycytidine
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2'-deoxyguanosine + ATP
2'-deoxyguanosine 5'-phosphate + ADP
Substrates: 53% of the activity with thymidine
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2'-deoxyguanosine + ATP
2'-deoxyguanosine 5'-phosphate + ADP
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Substrates: 4% of the activity with thymidine and 2'-deoxycytidine
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2'-deoxyuridine + ATP
2'-deoxyuridine 5'-phosphate + ADP
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Substrates: specificity constant 410 per s and M
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2'-deoxyuridine + ATP
2'-deoxyuridine 5'-phosphate + ADP
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Substrates: 113% of the activity with thymidine
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2'-deoxyuridine + ATP
2'-deoxyuridine 5'-phosphate + ADP
Substrates: 113% of the activity with thymidine
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2'-deoxyuridine + ATP
2'-deoxyuridine 5'-phosphate + ADP
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Substrates: 90% of the activity with thymidine and 2'-deoxycytidine
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2-chloro-2'-deoxyadenosine + ATP
2-chloro-2'-deoxyadenosine 5'-phosphate + ADP
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Substrates: 126% of the activity with thymidine
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2-chloro-2'-deoxyadenosine + ATP
2-chloro-2'-deoxyadenosine 5'-phosphate + ADP
Substrates: 126% of the activity with thymidine
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3'-azido-2',3'-dideoxythymidine + ATP
3'-azido-2',3'-dideoxythymidine 5'-phosphate + ADP
-
Substrates: -
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3'-azido-2',3'-dideoxythymidine + ATP
3'-azido-2',3'-dideoxythymidine 5'-phosphate + ADP
Substrates: 2% of the activity with thymidine
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3'-azidothymidine + ATP
3'-azidothymidine 5'-phosphate + ADP
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Substrates: 0.5% of the activity with thymidine and 2'-deoxycytidine
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3'-azidothymidine + ATP
3'-azidothymidine 5'-phosphate + ADP
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Substrates: 0.3% of the activity with thymidine and 2'-deoxycytidine
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5-fluoro-2'-deoxyuridine + ATP
5-fluoro-2'-deoxyuridine 5'-phosphate + ADP
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Substrates: 92% of the activity with thymidine
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5-fluoro-2'-deoxyuridine + ATP
5-fluoro-2'-deoxyuridine 5'-phosphate + ADP
Substrates: 92% of the activity with thymidine
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5-fluoro-2'-deoxyuridine + ATP
5-fluoro-2'-deoxyuridine 5'-phosphate + ADP
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Substrates: activity is 10% higher than with thymidine and 2'-deoxycytidine
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adenosine + ATP
adenosine 5'-phosphate + ADP
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Substrates: 0.82% of the activity with thymidine
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adenosine + ATP
adenosine 5'-phosphate + ADP
Substrates: 0.82% of the activity with thymidine
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ATP + 1-beta-D-arabinofuranosylcytosine
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
Substrates: low activity
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ATP + 1-beta-D-arabinofuranosylcytosine
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
Substrates: -
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ATP + 1-beta-D-arabinofuranosylcytosine
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
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Substrates: -
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ATP + 1-beta-D-arabinofuranosylcytosine
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
Substrates: -
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ATP + 1-beta-D-arabinofuranosylcytosine
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
Substrates: -
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ATP + 1-beta-D-arabinofuranosylthymine
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
Substrates: low activity
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ATP + 1-beta-D-arabinofuranosylthymine
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
Substrates: -
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ATP + 1-beta-D-arabinofuranosylthymine
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
Substrates: -
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ATP + 1-beta-D-arabinofuranosylthymine
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
Substrates: -
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ATP + 2',2'-difluorodeoxycytidine
ADP + 2',2'-difluorodeoxycytidine 5'-phosphate
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Substrates: -
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ATP + 2',2'-difluorodeoxycytidine
ADP + 2',2'-difluorodeoxycytidine 5'-phosphate
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Substrates: best substrate for the N-terminally truncated mutant M88R
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ATP + 2',3'-didehydro-3'-deoxythymidine
ADP + 2',3'-didehydro-3'-deoxythymidine 5'-phosphate
Substrates: low activity
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ATP + 2',3'-didehydro-3'-deoxythymidine
ADP + 2',3'-didehydro-3'-deoxythymidine 5'-phosphate
Substrates: -
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ATP + 2',3'-dideoxycytidine
ADP + 2',3'-dideoxycytidine 5'-phosphate
Substrates: -
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ATP + 2',3'-dideoxycytidine
ADP + 2',3'-dideoxycytidine 5'-phosphate
Substrates: low activity
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ATP + 2',3'-dideoxythymidine
ADP + 2',3'-dideoxythymidine 5'-phosphate
Substrates: -
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ATP + 2',3'-dideoxythymidine
ADP + 2',3'-dideoxythymidine 5'-phosphate
Substrates: low activity
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
Substrates: 48% of the activity with 2'-deoxythymidine
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
Substrates: 2.7% of the activity with 2'-deoxycytidine
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
Substrates: best substrate for the N-terminally truncated mutant V84A/M88R
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
Substrates: 1% of the activity with 2'-deoxythymidine
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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: high activity
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: 99% of the activity with 2'-deoxythymidine
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: best substrate
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
Substrates: wild-type enzyme: second-best substrate
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: 88% of the activity with 2'-deoxythymidine
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ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: high activity
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: 83% of the activity with 2'-deoxythymidine
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: 0.5% of the activity with 2'-deoxycytidine
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
Substrates: poor substrate for the wild-type enzyme
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
Substrates: poor substrate for the wild-type enzyme but moderate activity with N-terminally truncated mutants M88R and V84A/M88R
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: 0.2% of the activity with 2'-deoxythymidine
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ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
Substrates: -
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ATP + 2'-deoxynucleoside
ADP + 2'-deoxynucleoside 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxynucleoside
ADP + 2'-deoxynucleoside 5'-phosphate
-
Substrates: dNK has a significant preference for pyrimidine deoxynucleosides over purine deoxynucleosides, but it does phosphorylate deoxyadenosine and deoxyguanosine at significant rates
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ATP + 2'-deoxyribonucleoside
ADP + 2'-deoxyribonucleoside 5'-phosphate
Substrates: -
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ATP + 2'-deoxyribonucleoside
ADP + 2'-deoxyribonucleoside 5'-phosphate
Substrates: -
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ATP + 2'-deoxyribonucleoside
ADP + 2'-deoxyribonucleoside 5'-phosphate
Substrates: -
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ATP + 2'-deoxyribonucleoside
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxyribonucleoside
ADP + 2'-deoxyribonucleoside 5'-phosphate
Substrates: -
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ATP + 2'-deoxyribonucleoside
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: best substrate
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: high activity
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: 65% of the activity with 2'-deoxycytidine
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
Substrates: -
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: best substrate
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: 2'-deoxythymidine binding structure at the active site, overview
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
Substrates: best substrate for the wild-type enzyme
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
Substrates: substrate binding structure of mutant N64D
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: -
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ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
Substrates: best substrate
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ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
Substrates: best substrate
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ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
Substrates: high activity
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ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
Substrates: -
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ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
Substrates: low activity
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ATP + 3'-azido-2',3'-didehydro-3'-deoxythymidine
ADP + 3'-azido-2',3'-didehydro-3'-deoxythymidine 5'-phosphate
Substrates: low activity
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ATP + 3'-azido-2',3'-didehydro-3'-deoxythymidine
ADP + 3'-azido-2',3'-didehydro-3'-deoxythymidine 5'-phosphate
-
Substrates: -
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ATP + 3'-azido-2',3'-didehydro-3'-deoxythymidine
ADP + 3'-azido-2',3'-didehydro-3'-deoxythymidine 5'-phosphate
Substrates: low activity
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ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
Substrates: -
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ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
Substrates: high activity
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ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
Substrates: -
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ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
Substrates: high activity
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ATP + 9-beta-D-arabinofuranosyladenine
ADP + 9-beta-D-arabinofuranosyladenine 5'-phosphate