EC Number   |
Protein Variants |
Reference |
|---|
    2.3.1.12 | K244Q |
unlipoylatable domain |
486166 |
| 2.3.1.12 | K276A |
mutant shows negligible binding to human pyruvate dehydrogenase with 86fold higher KD compared to wild-type |
686772 |
| 2.3.1.12 | K96A |
mutation in potential lipoylation site, mutant protein entirely supports the assignment of Lys96 as the site of lipoylation |
720722 |
| 2.3.1.12 | K96R |
mutation in potential lipoylation site, mutant protein entirely supports the assignment of Lys96 as the site of lipoylation |
720722 |
| 2.3.1.12 | L140A |
mutation in the inner lipoyl-bearing domain (L2), pyruvate dehydrogenase kinase 2 binding: not measurable |
672273 |
| 2.3.1.12 | L189A |
ability to be post-translationally lipoylated remains |
486229 |
| 2.3.1.12 | M131A |
site-directed mutagenesis, thermodynamics and kinetics in comparison to the wild-type enzyme |
661632 |
| 2.3.1.12 | M194A |
ability to be post-translationally lipoylated remains |
486229 |
| 2.3.1.12 | M197A |
ability to be post-translationally lipoylated remains |
486229 |
| 2.3.1.12 | more |
a truncated version of dihydrolipoyl acetyltransferase is created lacking the N-terminal 319 amino acids |
690088 |
