EC Number   |
Protein Variants |
Reference |
|---|
    1.1.1.22 | C276G |
activity is not measurable at pH 8.7, 22°C |
667848 |
| 1.1.1.22 | C276K |
activity is not measurable at pH 8.7, 22°C |
667848 |
| 1.1.1.22 | C276L |
activity is not measurable at pH 8.7, 22°C |
667848 |
| 1.1.1.22 | C276S |
is a hexamer |
695880 |
| 1.1.1.22 | C276S |
no enzymic activity, affinity for NAD+ similar to wild-type, retains predominantly hexameric structure |
656220 |
| 1.1.1.22 | C276S |
site-directed mutagenesis, strong decrease in specific activity |
685143 |
| 1.1.1.22 | C276Y |
activity is not measurable at pH 8.7, 22°C |
667848 |
| 1.1.1.22 | D280A |
extremely poor enzymic activity |
725478 |
| 1.1.1.22 | D280E |
site-directed mutagenesis, 3-fold increase in Km for UDP-glucose and a 2-fold reduced Vmax relative to that of the wild type |
685143 |
| 1.1.1.22 | D280N |
an inactive UGDH mutant |
711665 |
