EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   6.2.1.64 | Neoplasms |
24155378 |
A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation. |
therapeutic application
unassigned |
3
0 |
| 6.2.1.64 | Neoplasms |
33560503 |
A first-in-human, phase 1 study of the NEDD8 activating enzyme E1 inhibitor TAS4464 in patients with advanced solid tumors. |
ongoing research
therapeutic application
unassigned |
3
2
0 |
| 6.2.1.64 | Neoplasms |
22832224 |
A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924. |
therapeutic application
unassigned |
4
0 |
| 6.2.1.64 | Stomach Neoplasms |
34258028 |
A Phase I study of pevonedistat plus capecitabine plus oxaliplatin in patients with advanced gastric cancer refractory to platinum (NCCH-1811). |
therapeutic application
unassigned |
4
0 |
| 6.2.1.64 | Melanoma |
27056178 |
A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma. |
ongoing research
therapeutic application
unassigned |
2
3
0 |
| 6.2.1.64 | Hematologic Neoplasms |
32059437 |
ABCG2 Overexpression Contributes to Pevonedistat Resistance. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 6.2.1.64 | Neoplasms |
32059437 |
ABCG2 Overexpression Contributes to Pevonedistat Resistance. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 6.2.1.64 | Multiple Myeloma |
31583781 |
Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor ?B pathways. |
causal interaction
unassigned |
4
0 |
| 6.2.1.64 | Neoplasms |
33898451 |
Advances in Cancer Treatment by Targeting the Neddylation Pathway. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 6.2.1.64 | Breast Neoplasms |
30198810 |
AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. |
therapeutic application
unassigned |
4
0 |
