EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
   6.2.1.64 | Alzheimer Disease |
12694406 |
ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 6.2.1.64 | Alzheimer Disease |
14557245 |
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. |
causal interaction
unassigned |
4
0 |
| 6.2.1.64 | Down Syndrome |
17611268 |
Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis. |
causal interaction
ongoing research
unassigned |
2
2
0 |
| 6.2.1.64 | Neoplasms |
19360080 |
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 6.2.1.64 | Neoplasms |
20129059 |
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. |
diagnostic usage
unassigned |
1
0 |
| 6.2.1.64 | Leukemia, Myeloid, Acute |
20203261 |
Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 6.2.1.64 | Lymphoma |
20525923 |
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. |
causal interaction
therapeutic application
unassigned |
3
3
0 |
| 6.2.1.64 | Lymphoma, B-Cell |
20525923 |
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. |
causal interaction
therapeutic application
unassigned |
3
3
0 |
| 6.2.1.64 | Lymphoma, Large B-Cell, Diffuse |
20525923 |
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. |
causal interaction
therapeutic application
unassigned |
3
3
0 |
| 6.2.1.64 | Alzheimer Disease |
20827337 |
Amyloid Precursor Protein Binding Protein-1 Is Up-regulated in Brains of Tg2576 Mice. |
causal interaction
ongoing research
unassigned |
4
4
0 |
