EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
6.2.1.15 | Adenocarcinoma |
11731423 |
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 2 4 |
6.2.1.15 | Adenocarcinoma of Lung |
34053456 |
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma. |
causal interaction diagnostic usage unassigned |
1 3 0 |
6.2.1.15 | Adenoma |
11731423 |
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 2 4 |
6.2.1.15 | arachidonate-coa ligase deficiency |
30721098 |
Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet. |
ongoing research unassigned |
4 0 |
6.2.1.15 | arachidonate-coa ligase deficiency |
31376475 |
Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages. |
causal interaction unassigned |
3 0 |
6.2.1.15 | arachidonate-coa ligase deficiency |
31504388 |
Tissue Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis. |
causal interaction unassigned |
3 0 |
6.2.1.15 | Atherosclerosis |
17259370 |
Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. |
causal interaction ongoing research unassigned |
1 4 0 |
6.2.1.15 | Atherosclerosis |
33974977 |
Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis. |
causal interaction diagnostic usage ongoing research therapeutic application |
3 2 2 1 |
6.2.1.15 | Brain Edema |
33314758 |
Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis. |
causal interaction therapeutic application unassigned |
4 1 0 |
6.2.1.15 | Brain Infarction |
33889074 |
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis. |
causal interaction ongoing research therapeutic application unassigned |
4 3 4 0 |