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ATP + 5,8,11,14,17-eicosapentaenoic acid + CoA
ATP + diphosphate + 5,8,11,14,17-eicosapentaenoyl-CoA
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Substrates: -
Products: -
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ATP + 5,8,11-eicosatrienoate + CoA
AMP + diphosphate + 5,8,11-eicosatrienoyl-CoA
-
Substrates: -
Products: -
?
ATP + 8,11,14-eicosatrienoate + CoA
AMP + diphosphate + 8,11,14-eicosatrienoyl-CoA
ATP + arachidonate + CoA
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
ATP + docosahexaenoate + CoA
ATP + diphosphate + docosahexaenoyl-CoA
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Substrates: -
Products: -
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ATP + 8,11,14-eicosatrienoate + CoA
AMP + diphosphate + 8,11,14-eicosatrienoyl-CoA
-
Substrates: -
Products: -
?
ATP + 8,11,14-eicosatrienoate + CoA
AMP + diphosphate + 8,11,14-eicosatrienoyl-CoA
-
Substrates: -
Products: -
?
ATP + arachidonate + CoA
?
-
Substrates: enzyme may control the level of free arachidonate in platelets, limiting prostaglandin synthesis by the unstimulated cell and capturing free arachidonate from extracellular sources
Products: -
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ATP + arachidonate + CoA
?
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Substrates: enzyme is required for arachidonate homeostasis in HSDM1C1 cells
Products: -
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ATP + arachidonate + CoA
?
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Substrates: possible role in lymphocyte activation and as a homeostatic mechanism during essential fatty acid deficiency
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
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Substrates: -
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
Substrates: -
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
Substrates: preferred substrate
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
Substrates: arachidonic acid is a preferred substrate for ACSL4 variant 1 in intact human smooth muscle cells
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
Substrates: -
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
Substrates: -
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
Substrates: -
Products: -
?
ATP + arachidonate + CoA
AMP + diphosphate + arachidonoyl-CoA
-
Substrates: -
Products: -
?
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Hartman, E.J.; Omura, S.; Laposata, M.
Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase
Prostaglandins
37
655-671
1989
Mus musculus
brenda
Morand, O.; Carre, J.B.; Homayoun, P.; Niel, E.; Baumann, N.; Bourre, J.M.
Arachidonoyl-coenzyme A synthetase and nonspecific acyl-coenzyme A synthetase activities in purified rat brain microvessels
J. Neurochem.
48
1150-1156
1987
Rattus norvegicus
brenda
Gerritsen, M.E.; Perry, C.A.
Regulation of eicosanoid synthesis in microvessel endothelium: glucocorticoids do not affect arachidonyl CoA synthetase activity
Biochim. Biophys. Acta
1045
174-179
1990
Oryctolagus cuniculus
brenda
Bakken, A.M.; Farstad, M.
Identical subcellular distribution of palmitoyl-CoA and arachidonoyl-CoA synthetase activities in human blood platelets
Biochem. J.
261
71-76
1989
Homo sapiens
brenda
Bakken, A.M.; Farstad, M.; Holmsen, H.
Identity between palmitoyl-CoA synthetase and arachidonoyl-CoA synthetase in human platelets?
Biochem. J.
274
145-152
1991
Homo sapiens
brenda
Hornberger, W.; Patscheke, H.
Primary stimuli of icosanoid release inhibit arachidonoyl-CoA synthetase and lysophospholipid acyltransferase. Mechanism of action of hydrogen peroxide and methyl mercury in platelets
Eur. J. Biochem.
187
175-181
1990
Homo sapiens
brenda
Laposata, M.; Reich, E.L.; Majerus, P.W.
Arachidonoyl-CoA synthetase. Separation from nonspecific acyl-CoA synthetase and distribution in various cells and tissues
J. Biol. Chem.
260
11016-11020
1985
Bos taurus, Homo sapiens
brenda
Taylor, A.S.; Sprecher, H.; Russel, J.H.
Characterization of an arachidonic acid-selective acyl-CoA synthetase from murine T lymphocytes
Biochim. Biophys. Acta
833
229-238
1985
Mus musculus
brenda
Neufeld, E.J.; Sprecher, H.; Evans, R.W.; Majerus, P.W.
Fatty acid structural requirements for activity of arachidonoyl-CoA synthetase
J. Lipid Res.
25
288-293
1984
Homo sapiens
brenda
Neufeld, E.J.; Bross, T.E.; Majerus, P.W.
A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase
J. Biol. Chem.
259
1986-1992
1984
Mus musculus
brenda
Reddy, T.S.; Bazan, N.G.
Kinetic properties of arachidonoyl-coenzyme A synthetase in rat brain microsomes
Arch. Biochem. Biophys.
226
125-133
1983
Rattus norvegicus
brenda
Wilson, D.B; Prescott, S.M.; Majerus, P.W.
Discovery of an arachidonoyl coenzyme A synthetase in human platelets
J. Biol. Chem.
257
3510-3515
1982
Homo sapiens
brenda
Laposata, M.
Solubilization of arachidonate-CoA ligase from cell membranes, chromatographic separation from nonspecific long-chain fatty acid CoA ligase, and isolation of mutant cell line defective in arachidonate-CoA ligase
Methods Enzymol.
187
237-242
1990
Bos taurus, Homo sapiens, Mus musculus
brenda
D'Antuono, C.L.; Kahane, V.L.; Sterin-Speziale, N.
Changes in the kinetic properties of renal arachidonoyl-CoA synthetase during development in the rat
Biol. Neonate
73
99-105
1998
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Golej, D.L.; Askari, B.; Kramer, F.; Barnhart, S.; Vivekanandan-Giri, A.; Pennathur, S.; Bornfeldt, K.E.
Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2 release from human arterial smooth muscle cells
J. Lipid Res.
52
782-793
2011
Homo sapiens (O60488), Homo sapiens
brenda
Maloberti, P.M.; Duarte, A.B.; Orlando, U.D.; Pasqualini, M.E.; Solano, A.R.; Lopez-Otin, C.; Podesta, E.J.
Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells
PLoS ONE
5
e15540
2010
Homo sapiens
brenda