EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.B29 | Adenocarcinoma |
23329366 |
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
4
1 |
| 3.4.22.B29 | Albuminuria |
15665521 |
Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease. |
causal interaction
unassigned |
1
0 |
| 3.4.22.B29 | Alzheimer Disease |
17157313 |
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. |
causal interaction
ongoing research
unassigned |
1
3
0 |
| 3.4.22.B29 | Breast Neoplasms |
25539577 |
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
2
3
0 |
| 3.4.22.B29 | Carcinogenesis |
10906334 |
Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.4.22.B29 | Carcinogenesis |
20686710 |
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. |
diagnostic usage
unassigned |
1
0 |
| 3.4.22.B29 | Carcinogenesis |
24721324 |
Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/?-catenin signaling while up-regulating ligand dependent transcription factor PPAR? |
ongoing research
therapeutic application
unassigned |
2
1
0 |
| 3.4.22.B29 | Carcinogenesis |
27404891 |
Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
2
4 |
| 3.4.22.B29 | Colorectal Neoplasms |
22390894 |
Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: Exploring NHE-1, intracellular calcium homeostasis and Calpain 9. |
therapeutic application
unassigned |
1
0 |
| 3.4.22.B29 | Diabetes Mellitus, Type 2 |
11516996 |
The calpain family and human disease. |
causal interaction
diagnostic usage
unassigned |
4
1
0 |
