calpain-9 may play a role in breast cance, low expression is associated with poorer patient clinical outcome following endocrine therapy, but no associations are observed between calpain-9 expression and clinicopathological variables
TGFbeta-induced mesenchymal transition of a murine breast epithelial cell line is dependent on induction of expression of calpain 9. Mice lacking functional CAPN9 are viable and fertile but show overt protection from bleomycin-induced lung fibrosis, carbon tetrachloride-induced liver fibrosis, and angiotensin II-induced cardiac fibrosis and dysfunction
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hanging drop vapor diffusion method, minicalpain 9. The structures of the highly conserved, ubiquitously expressed human calpain 1 and the more tissue specific human calpain 9 indicate that although there are high levels of sequence conservation throughout the calpain family, isolated structures of family members are insufficient to explain the molecular mechanism of activation for this group of proteins
low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer, but no associations are observed between calpain-9 expression and clinicopathological variables
single nucleotide polymorphisms G7518A and C7542G are associated with carcass weight, evisceration weight, abdominal fat weight, abdominal fat percentage, and breast muscle percentage. The AA(7518)/GG(7542) genotype has the highest intramuscular fat content, highest breast muscle weight, and lower abdominal fat weight and abdominal fat percentage