EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
   2.7.11.20 | Starvation |
1448107 |
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. |
therapeutic application
unassigned |
2
0 |
| 2.7.11.20 | Starvation |
7623840 |
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. |
ongoing research
unassigned |
1
0 |
| 2.7.11.20 | Starvation |
8497269 |
GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 2.7.11.20 | Glioma |
9056675 |
Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
4
1
0 |
| 2.7.11.20 | Starvation |
9234705 |
Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. |
unassigned |
0 |
| 2.7.11.20 | Brain Ischemia |
10072297 |
Eukaryotic initiation factor 2alpha kinase and phosphatase activity during postischemic brain reperfusion. |
ongoing research
therapeutic application
unassigned |
2
1
0 |
| 2.7.11.20 | Breast Neoplasms |
10408694 |
Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
1 |
| 2.7.11.20 | Neoplasms |
11101152 |
Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2alpha kinase: down-regulated in epithelial ovarian cancers. |
causal interaction
unassigned |
2
0 |
| 2.7.11.20 | Neoplasms |
11333223 |
Minimum requirements for the function of eukaryotic translation initiation factor 2. |
unassigned |
0 |
| 2.7.11.20 | Starvation |
11408481 |
The protein kinase Gcn2p mediates sodium toxicity in yeast. |
unassigned |
0 |
