EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
    1.14.14.17 | Hypercholesterolemia |
1649182 |
Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.14.14.17 | Demyelinating Diseases |
1700139 |
Tellurium-induced neuropathy: a model for reversible reductions in myelin protein gene expression. |
therapeutic application
unassigned |
1
0 |
| 1.14.14.17 | Demyelinating Diseases |
1721994 |
Primary demyelination induced by exposure to tellurium alters mRNA levels for nerve growth factor receptor, SCIP, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteolipid protein in rat sciatic nerve. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
1
2 |
| 1.14.14.17 | Demyelinating Diseases |
1940906 |
Tellurium-induced alterations in 3-hydroxy-3-methylglutaryl-CoA reductase gene expression and enzyme activity: differential effects in sciatic nerve and liver suggest tissue-specific regulation of cholesterol synthesis. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 1.14.14.17 | Carcinoma, Hepatocellular |
1964954 |
Regulation of squalene epoxidase in HepG2 cells. |
ongoing research
unassigned |
4
0 |
| 1.14.14.17 | Muscular Diseases |
9300786 |
Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts. |
causal interaction
therapeutic application
unassigned |
1
3
0 |
| 1.14.14.17 | Demyelinating Diseases |
9804288 |
Role of organotellurium species in tellurium neuropathy. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
4
3
0 |
| 1.14.14.17 | Demyelinating Diseases |
11181753 |
Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls. |
unassigned |
0 |
| 1.14.14.17 | Dermatitis |
12467639 |
Squalene epoxidase as hypocholesterolemic drug target revisited. |
causal interaction
therapeutic application
unassigned |
3
3
0 |
| 1.14.14.17 | Mycoses |
12956204 |
The efficacy and safety of terbinafine in children. |
diagnostic usage
therapeutic application
unassigned |
3
1
0 |
