EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.7.11.20 | Anemia |
17932563 |
The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. |
unassigned |
0 |
| 2.7.11.20 | Atherosclerosis |
25475470 |
Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
4
4
0 |
| 2.7.11.20 | Atherosclerosis |
32088293 |
Eukaryotic Elongation Factor 2 Kinase a Pharmacological Target to Regulate Protein Translation Dysfunction in Neurological Diseases. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.7.11.20 | beta-Thalassemia |
15931390 |
Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. |
causal interaction
unassigned |
2
0 |
| 2.7.11.20 | beta-Thalassemia |
17932563 |
The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. |
unassigned |
0 |
| 2.7.11.20 | beta-Thalassemia |
18367482 |
Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. |
causal interaction
ongoing research
unassigned |
4
4
0 |
| 2.7.11.20 | Brain Ischemia |
10072297 |
Eukaryotic initiation factor 2alpha kinase and phosphatase activity during postischemic brain reperfusion. |
ongoing research
therapeutic application
unassigned |
2
1
0 |
| 2.7.11.20 | Brain Ischemia |
15006693 |
Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia. |
ongoing research
therapeutic application
unassigned |
2
1
0 |
| 2.7.11.20 | Brain Neoplasms |
32027127 |
Design, Synthesis, and Molecular Modeling Studies of Novel Coumarin Carboxamide Derivatives as eEF-2K Inhibitors. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
1 |
| 2.7.11.20 | Breast Neoplasms |
10408694 |
Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
1 |
