EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
6.3.2.8 | 0.001 |
- |
(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol |
pH and temperature not specified in the publication |
743924 |
6.3.2.8 | 0.0000005 |
- |
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol |
below, pH and temperature not specified in the publication |
743924 |
6.3.2.8 | 0.000002 |
- |
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol |
pH and temperature not specified in the publication |
743924 |
6.3.2.8 | 0.0000007 |
- |
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol |
pH 8.0, 25°C, recombinant enzyme |
744050 |
6.3.2.8 | 0.000012 |
- |
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol |
pH 8.0, 25°C, recombinant enzyme |
744050 |
6.3.2.8 | 0.0000012 |
- |
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol |
pH and temperature not specified in the publication |
743924 |
6.3.2.8 | 0.000015 |
- |
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol |
pH and temperature not specified in the publication |
743924 |
6.3.2.8 | 0.000008 |
- |
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol |
pH and temperature not specified in the publication |
743924 |
6.3.2.8 | 0.000057 |
- |
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol |
pH and temperature not specified in the publication |
743924 |
6.3.2.8 | 0.0000005 |
- |
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol |
below, pH and temperature not specified in the publication |
743924 |