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ATP + dihydro-UDP-N-acetylmuramate + L-Ala
ADP + phosphate + dihydro-UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + glycine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-glycine
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
ATP + UDP-N-acetyl-alpha-D-muramate + L-serine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-serine
ATP + UDP-N-acetyl-beta-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-beta-D-muramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylglucosaminyl-enoylpyruvate + L-Ala
ADP + phosphate + UDP-N-acetylglucosaminyl-enoylpyruvoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylglucosyl-enolpyruvate + L-alanine
ADP + phosphate + UDP-N-acetylglucosyl-enolpyruvoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-benzylpropionate
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-benzylpropionate
-
-
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-ethylpropionate
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-ethylpropionate
-
-
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-methylpropionate
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-methylpropionate
-
-
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-N-butyric acid
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-butyric acid
ATP + UDP-N-acetylmuramate + 2-amino-N-hydroxymethyl propionamide
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-hydroxymethylpropionamide
-
-
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-propionamide
ADP + phosphate + UDP-N-acetylmuramoyl-2-aminopropionamide
-
-
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-tert-butylpropionate
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-tert-butylpropionate
-
-
-
-
?
ATP + UDP-N-acetylmuramate + benzyl L-alaninate
ADP + phosphate + benzyl UDP-N-acetylmuramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + beta-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-beta-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + beta-chloro-L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-beta-chloro-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + beta-cyano-L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-beta-cyano-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + DL-propargylglycine
ADP + phosphate + UDP-N-acetylmuramoyl-DL-propargylglycine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + DL-Ser
ADP + phosphate + UDP-N-acetylmuramoyl-DL-Ser
ATP + UDP-N-acetylmuramate + ethyl L-alaninate
ADP + phosphate + ethyl UDP-N-acetylmuramoyl-L-alaninate
-
-
-
-
?
ATP + UDP-N-acetylmuramate + Gly
ADP + phosphate + UDP-N-acetylmuramoyl-Gly
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
ATP + UDP-N-acetylmuramate + L-Ala
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
ATP + UDP-N-acetylmuramate + L-Cys
ADP + phosphate + UDP-N-acetylmuramoyl-L-Cys
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ile
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ile
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-serine
ADP + phosphate + UDP-N-acetylmuramoyl-L-serine
ATP + UDP-N-acetylmuramate + L-Thr
ADP + phosphate + UDP-N-acetylmuramoyl-L-Thr
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Val
ADP + phosphate + UDP-N-acetylmuramoyl-L-Val
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-vinylglycine
ADP + phosphate + UDP-N-acetylmuramoyl-L-vinylglycine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + methyl L-alaninate
ADP + phosphate + methyl UDP-N-acetylmuramoyl-L-alaninate
-
-
-
-
?
ATP + UDP-N-acetylmuramate + N-(2-aminopropionyl)piperidine
ADP + phosphate + UDP-N-acetylmuramoyl-N-(2-aminopropionyl)piperidine
-
-
-
-
?
UTP + UDP-N-acetylmuramate + L-Ala
UDP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
about 11% of the activity relative to ATP
-
?
additional information
?
-
ATP + UDP-N-acetyl-alpha-D-muramate + glycine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-glycine
-
reduced activity with glycine compared to L-alanine
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + glycine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-glycine
-
reduced activity with glycine compared to L-alanine
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
determination by phosphate detection using malachite green reagent
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
Nostoc sp. PCC 7120 = FACHB-418 SAG 25.82 / UTEX 2576
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
determination by phosphate detection using malachite green reagent
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-serine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-serine
-
reduced activity with L-serine compared to L-alanine
-
-
?
ATP + UDP-N-acetyl-alpha-D-muramate + L-serine
ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-serine
-
reduced activity with L-serine compared to L-alanine
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-N-butyric acid
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-butyric acid
-
-
-
-
?
ATP + UDP-N-acetylmuramate + 2-amino-N-butyric acid
ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-butyric acid
-
-
-
-
?
ATP + UDP-N-acetylmuramate + DL-Ser
ADP + phosphate + UDP-N-acetylmuramoyl-DL-Ser
-
-
-
-
?
ATP + UDP-N-acetylmuramate + DL-Ser
ADP + phosphate + UDP-N-acetylmuramoyl-DL-Ser
-
-
-
-
?
ATP + UDP-N-acetylmuramate + Gly
ADP + phosphate + UDP-N-acetylmuramoyl-Gly
-
-
-
-
?
ATP + UDP-N-acetylmuramate + Gly
ADP + phosphate + UDP-N-acetylmuramoyl-Gly
-
-
-
-
?
ATP + UDP-N-acetylmuramate + Gly
ADP + phosphate + UDP-N-acetylmuramoyl-Gly
-
-
-
?
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
-
-
r
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
-
-
r
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
-
-
r
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
-
-
r
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
-
-
r
ATP + UDP-N-acetylmuramate + glycine
ADP + phosphate + UDP-N-acetylmuramoyl-glycine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
?
-
adds the first amino acid to the sugar moiety of the peptidoglycan precursor, catalyzing one essential step in cell wall biosynthesis
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
?
-
formation of a acylphosphate intermediate
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
?
-
enzyme activity is not in excess in the cell under normal growth conditions, but the amount is adjusted to the requirements of peptidoglycan synthesis
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
r
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
alpha- and beta-anomer of UDP-N-acetylmuramate
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
not active with D-Ala
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
accepts L-Ala, L-Ser and Gly as substrates, with a strong preference for L-Ala
-
-
?
ATP + UDP-N-acetylmuramate + L-Ala
ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
r
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
r
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
MurC is essential for peptidoglycan biosynthesis and is responsible of the addition of the first residue L-alanine onto the nucleotide precursor UDP-MurNAc. It is regulated by the serine/threonine protein kinase PknA, overview
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
r
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
r
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
r
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
?
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
-
-
?
ATP + UDP-N-acetylmuramate + L-serine
ADP + phosphate + UDP-N-acetylmuramoyl-L-serine
-
-
-
r
ATP + UDP-N-acetylmuramate + L-serine
ADP + phosphate + UDP-N-acetylmuramoyl-L-serine
-
-
-
r
ATP + UDP-N-acetylmuramate + L-serine
ADP + phosphate + UDP-N-acetylmuramoyl-L-serine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-serine
ADP + phosphate + UDP-N-acetylmuramoyl-L-serine
-
-
-
-
?
ATP + UDP-N-acetylmuramate + L-serine
ADP + phosphate + UDP-N-acetylmuramoyl-L-serine
-
-
-
-
?
additional information
?
-
-
regulation by reversible phosphorylation, overview
-
-
?
additional information
?
-
-
the enzyme hydrolyzes ATP in absence of L-Ala. This L-Ala independent activity is dependent upon the concentration of both ATP and UDP-N-acetylmuramate
-
-
?
additional information
?
-
-
enzyme catalyzes an exchange reaction leading to the formation of 4% of the UDP-N-acetylmuramoyl-L-[14C]Ala with UDP-N-acetylmuramoyl-L-Ala, L-[14C]Ala, ADP and phosphate
-
-
?
additional information
?
-
-
the Mur ligases constitute a series of four ATP-dependent enzymes, MurC to Mur, that are responsible for the stepwise addition of the pentapeptide side chain onto the D-lactoyl group of the uridine diphosphate-N-acetylmuramic acid initially formed via MurA and MurB, MurC catalyzes the additon of the first amino acid L-alanine. All of the Mur ligases catalyze the formation of an amide or peptide bond through the same reaction mechanism via a tetrahedral intermediate, overview
-
-
?
additional information
?
-
-
MurC is able to incorporate glycine and L-Ala to UDP-MurNAc in Mycobacterium tuberculosis, the enzyme is highly specific for ATP and UDP-N-acetylmuramate, poor activity with ADP, GTP, CTP, UTP, and dTTP
-
-
?
additional information
?
-
-
MurC is able to incorporate glycine and L-Ala to UDP-MurNAc in Mycobacterium tuberculosis, the enzyme is highly specific for ATP and UDP-N-acetylmuramate, poor activity with ADP, GTP, CTP, UTP, and dTTP
-
-
?
additional information
?
-
-
in contrast to the UDP-N-acetylmuramate:L-alanine ligase (MurC) activity, the activity of the UDP-N-acetylenolpyruvoylglucosamine reductase (MurB, EC 1.3.1.98) cannot be detected in vitro
-
-
?
additional information
?
-
-
in contrast to the UDP-N-acetylmuramate:L-alanine ligase (MurC) activity, the activity of the UDP-N-acetylenolpyruvoylglucosamine reductase (MurB, EC 1.3.1.98) cannot be detected in vitro
-
-
?
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(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
(2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
(2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
(2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol
(2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
(5Z)-5-([2-[(4-chlorobenzyl)sulfanyl]-5-nitrophenyl]methylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-([4-[(E)-2-phenylethenyl]phenyl]methylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
1H-indazole-3-carbohydrazide
-
-
2-((4-[(2S)-butan-2-ylamino]-6-(ethylamino)-1,3,5-triazin-2-yl)sulfanyl)-N-(2-chlorophenyl)acetamide
0.5 mM, 26% inhibition
2-(4-{[(E)-2-(1H-indazol-3-ylcarbonyl)hydrazono]methyl} phenoxy) acetic acid
-
complete inhibition at 0.5 mM
2-([2-(2-naphthylsulfonyl)hydrazono)methyl]phenyl 2-nitrobenzenesulfonate
-
55% inhibition at 0.05 mM
2-([2-(2-naphthylsulfonyl)hydrazono)methyl]phenyl 3-nitrobenzenesulfonate
-
65% inhibition at 0.05 mM
2-([2-(2-naphthylsulfonyl)hydrazono)methyl]phenyl 4-nitrobenzenesulfonate
-
75% inhibition at 0.10 mM
2-([2-(naphthalen-2-ylsulfonyl)hydrazono]methyl)phenyl 2-(benzo[d][1,3]dioxol-5-yl)acetate
-
57% inhibition at 0.10 mM
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
2-bromo-N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)benzamide
-
41% inhibition at 0.10 mM
2-phenyl-1,3-thiazole-5-carbohydrazide
-
-
2-phenyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-1,3-thiazole-5-carbohydrazide
-
18% inhibition at 0.25 mM
2-[4-({(E)-2-[(4-methyl-1,3-thiazol-5-yl)carbonyl]hydrazono} methyl)phenoxy]acetic acid
-
complete inhibition at 0.5 mM
3,3,3-Trifluoro-DL-Ala
-
-
3-bromo-N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)benzamide
-
-
4-([(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl)-6-(naphthalen-2-ylmethyl)-1,3,5-triazin-2-amine
0.5 mM, 30% inhibition
4-({(E)-2-[(4-methyl-1,3-thiazol-5-yl)carbonyl]hydrazono} methyl)benzoic acid
-
94% inhibition at 0.5 mM
4-cyano-N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)benzamide
-
91% inhibition at 0.05 mM
4-methyl-1,3-thiazole-5-carbohydrazide
-
-
4-methyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-1,3-thiazole-5-carbohydrazide
-
26% inhibition at 0.5 mM
4-methyl-N'-[(E)-(2-phenyl-1,3-thiazol-4-yl)methylidene]-1,3-thiazole-5-carbohydrazide
-
complete inhibition at 0.5 mM
4-{[(E)-2-(1H-indazol-3-ylcarbonyl)hydrazono]methyl}benzoic acid
-
complete inhibition at 0.5 mM
5-methyl-N-([4-(5-phenyl-1-benzofuran-2-yl)phenyl]sulfonyl)thiophene-2-carboxamide
-
IC50 2.3 microM
6-([(1,1-dioxidotetrahydrothiophen-3-yl)sulfanyl]methyl)-N-(2-phenylethyl)-1,3,5-triazine-2,4-diamine
0.25 mM, 32% inhibition
6-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
0.5 mM, 36% inhibition
Ba2+
-
inhibits activation by Mn2+
benzylidene rhodanines
-
possess MurC inhibitory activity in the low micromolar range
-
beta-gamma-methyleneadenosine 5'-triphosphate
-
-
Cd2+
-
inhibits activation by Mn2+
Co2+
-
inhibits activation by Mn2+
Fe2+
-
inhibits activation by Mn2+
Hg2+
-
inhibits activation by Mn2+
KCl
-
inhibition above 100 mM
L-Ala-L-1-aminoethylphosphinic acid
-
i.e. alaphosphin
methyl4-({(E)-2-[(4-methyl-1,3-thiazol-5-yl)carbonyl]hydrazono}methyl)benzoate
-
95% inhibition at 0.5 mM
methyl4-{[(E)-2-(1H-indazol-3-ylcarbonyl)hydrazono]methyl} benzoate
-
complete inhibition at 0.5 mM
Mg2+
-
inhibits activation by Mn2+
N'-((2-[(2-nitrobenzyl)oxy]phenyl)methylidene)-2-naphthalenesulfonohydrazide
-
30% inhibition at 0.10 mM
N'-((2-[(3-nitrobenzyl)oxy]phenyl)methylidene)-2-naphthalenesulfonohydrazide
-
36% inhibition at 0.05 mM
N'-((2-[(4-cyanobenzyl)oxy]phenyl)methylidene)(2-fluorophenyl)methanesulfonohydrazide
-
59% inhibition at 0.10 mM
N'-((2-[(4-cyanobenzyl)oxy]phenyl)methylidene)(phenyl)methanesulfonohydrazide
-
complete inhibition at 0.10 mM
N'-((2-[(4-cyanobenzyl)oxy]phenyl)methylidene)-2-naphthalenesulfonohydrazide
-
36% inhibition at 0.10 mM
N'-((2-[(4-cyanobenzyl)oxy]phenyl)methylidene)-2-nitrobenzenesulfonohydrazide
-
95% inhibition at 0.01 mM
N'-((2-[(4-cyanobenzyl)oxy]phenyl)methylidene)-3-nitrobenzenesulfonohydrazide
-
-
N'-((2-[(4-cyanobenzyl)oxy]phenyl)methylidene)[4-(trifluoromethyl)phenyl]methanesulfonohydrazide
-
-
N'-((3-[(3-nitrobenzyl)oxy]phenyl)methylidene)-2-naphthalenesulfonohydrazide
-
58% inhibition at 0.05 mM
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-1H-indazole-3-carbohydrazide
-
42% inhibition at 0.25 mM
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide
-
64% inhibition at 0.10 mM
N'-[(E)-(2,4-dihydroxyphenyl)methylidene]-1H-indazole-3-carbohydrazide
-
74% inhibition at 0.25 mM
N'-[(E)-(2-hydroxyphenyl)methylidene]-1H-indazole-3-carbohydrazide
-
complete inhibition at 0.25 mM
N'-[(E)-(2-phenyl-1,3-thiazol-4-yl)methylidene]-1H-indazole-3-carbohydrazide
-
78% inhibition at 0.10 mM
N'-[(E)-(2-phenyl-1,3-thiazol-4-yl)methylidene]benzohydrazide
-
70% inhibition at 0.25 mM
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-1H-indazole-3-carbohydrazide
-
36% inhibition at 0.5 mM
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-1,3-thiazole-5-carbohydrazide
-
95% inhibition at 0.5 mM
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]benzohydrazide
-
complete inhibition at 0.5 mM
N'-[(E)-(3,4-dimethoxyphenyl)methylidene]-1H-indazole-3-carbohydrazide
-
complete inhibition at 0.5 mM
N'-[(E)-(3,4-dimethoxyphenyl)methylidene]-4-methyl-1,3-thiazole-5-carbohydrazide
-
complete inhibition at 0.5 mM
N'-[(E)-(3,4-dimethoxyphenyl)methylidene]benzohydrazide
-
97% inhibition at 0.5 mM
N'-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-4-methyl-1,3-thiazole-5-carbohydrazide
-
43% inhibition at 0.25 mM
N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene] benzohydrazide
-
92% inhibition at 0.5 mM
N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene]-1H-indazole-3-carbohydrazide
-
67% inhibition at 0.25 mM
N'-[(E)-(4-cyanophenyl)methylidene]-1H-indazole-3-carbohydrazide
-
complete inhibition at 0.25 mM
N'-[(E)-(4-cyanophenyl)methylidene]benzohydrazide
-
complete inhibition at 0.25 mM
N'-[(E)-(4-nitrophenyl)methylidene]-1H-indazole-3-carbohydrazide
-
91% inhibition at 0.5 mM
N'-[(E)-1H-indol-3-ylmethylidene]-1H-indazole-3-carbohydrazide
-
complete inhibition at 010 mM
N'-[(E)-1H-indol-3-ylmethylidene]benzohydrazide
-
93% inhibition at 0.5 mM
N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-1H-indazole-3-carbohydrazide
-
95% inhibition at 0.25 mM
N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-4-methyl-1,3-thiazole-5-carbohydrazide
-
97% inhibition at 0.25 mM
N'-{(E)-[4-(dimethylamino)phenyl]methylidene}benzohydrazide
-
complete inhibition at 0.25 mM
N-(2-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-3,5-dinitrobenzamide
-
51% inhibition at 0.10 mM
N-(2-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-4-nitrobenzamide
-
-
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-2-naphthamide
-
-
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-2-nitrobenzamide
-
-
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-3,5-dinitrobenzamide
-
72% inhibition at 0.10 mM
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-4-nitrobenzamide
-
71% inhibition at 0.05 mM
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)benzamide
-
97% inhibition at 0.10 mM
N-[(E)-(2,4-dihydroxyphenyl)methylidene]benzohydrazide
-
complete inhibition at 0.5 mM
NaCl
-
inhibition above 100 mM
p-hydroxymercuribenzoate
-
partial protection by ATP
potassium phosphate
-
no effect up to 20 mM, significant decrease of activity at higher concentrations
UDP-2-(acetylamino)-4-O-[[(2-carboxypropyl)(hydroxy)phosphoryl]methyl]-2-deoxy-alpha-D-glucopyranose
-
-
UDP-N-acetylmuramoyl-L-Ala
-
-
(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol
-
-
(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol
-
-
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
-
-
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
-
-
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
-
a pyrazolopyrimidine, is a potent inhibitor of the enzyme and is active against an efflux pump mutant of Escherichia coli, but cellular activity against Escherichia coli is not observed. MIC values for (2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol are 0.2 mM for wild-type Escherichia coli and 0.0125 for Escherichia coli tolC mutant
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
-
a pyrazolopyrimidine, is a potent inhibitor of the enzyme and is active against an efflux pump mutant of Pseudomonas aeruginosa, but cellular activity against Pseudomonas aeruginosa is not observed. MIC values for (2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol are over 0.2 mM for wild-type Pseudomonas aeruginosa and 0.0065 mM against the Pseudomonas aeruginosa mutant strain DELTAmexADCDXY
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
-
-
(2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
-
-
(2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
-
-
(2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
-
-
(2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
-
-
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
-
-
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
-
-
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
-
-
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
-
-
(2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol
-
-
(2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol
-
-
(2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
-
-
(2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
-
-
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
-
-
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
-
-
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
-
-
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
-
-
Ca2+
-
-
Ca2+
-
inhibits activation by Mn2+
feglymycin
-
isolated from Streptomyces sp. DSM 11171, 13-mer peptide, noncompetitive inhibition, the inhibition is fully reversible after dilution
feglymycin
-
isolated from Streptomyces sp. DSM 11171, 13-mer peptide, noncompetitive inhibition, the inhibition is fully reversible after dilution
Gly
-
-
L-Ser
-
inhibits reaction with Gly + N-acetylmuramate + ATP
NEM
-
-
NEM
-
partial protection by ATP
Ni2+
-
-
Ni2+
-
inhibits activation by Mn2+
Zn2+
-
-
Zn2+
-
inhibits activation by Mn2+
additional information
-
synthesis and evaluation of a series of transition-state analog inhibitors
-
additional information
-
inhibitor design and synthesis, mass spectrometric analysis, ligand molecular docking calculations, inhibitory potency, MIC values lay above 0.128 mg/ml, overview
-
additional information
-
design and synthesis of N-benzylidenesulfonohydrazide inhibitors of MurC as antibacterial agents
-
additional information
-
a class of pyrazolopyrimidines with subnanomolar potency against both Escherichia coli and Pseudomonas aeruginosa MurC enzymes is constructed, which demonstrate a concomitant bactericidal activity against efflux-deficient strains. The compounds selectively inhibit peptidoglycan biosynthesis. In the presence of permeability enhancers such as colistin, pyrazolopyrimidines exhibit low micromolar MIC against the wild-type bacteria, thereby, indicating permeability and efflux as major challenges for this chemical series. Inhibitors evaluation and binding mode of pyrazolopyrimidines, docking study, overview
-
additional information
-
a class of pyrazolopyrimidines with subnanomolar potency against both Escherichia coli and Pseudomonas aeruginosa MurC enzymes is constructed, which demonstrate a concomitant bactericidal activity against efflux-deficient strains. The compounds selectively inhibit peptidoglycan biosynthesis. In the presence of permeability enhancers such as colistin, pyrazolopyrimidines exhibit low micromolar MIC against the wild-type bacteria, thereby, indicating permeability and efflux as major challenges for this chemical series. Inhibitors evaluation and binding mode of pyrazolopyrimidines, docking study, overview. The antibiotics linezolid, erythromycin, meropenem, ampicillin, and ofloxacin modulate the MIC values of pyrazolopyrimidine compounds in strain Pae546
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0.001
(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000005 - 0.000002
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
0.0000007 - 0.000012
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
0.0000012 - 0.000015
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
0.000008 - 0.000057
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
0.0000005 - 0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
0.000007 - 0.00006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
0.000004 - 0.000021
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
0.000008 - 0.00004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
0.000009
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000001 - 0.000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
0.0000007 - 0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
0.000002 - 0.000003
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
0.0000006 - 0.000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
0.000006 - 0.000052
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
0.000001 - 0.0000013
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
0.000007 - 0.00006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
0.0000005 - 0.000003
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
0.00001
(2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008
(2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000005
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008 - 0.000011
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
0.00005
(2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0001
(2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.027
(5Z)-5-([2-[(4-chlorobenzyl)sulfanyl]-5-nitrophenyl]methylidene)-2-thioxo-1,3-thiazolidin-4-one
Escherichia coli
-
pH 8.0, 37°C
0.018
(5Z)-5-([4-[(E)-2-phenylethenyl]phenyl]methylidene)-2-thioxo-1,3-thiazolidin-4-one
Escherichia coli
-
pH 8.0, 37°C
0.123
1H-indazole-3-carbohydrazide
Escherichia coli
-
pH 8.0, 37°C
0.000011 - 0.000101
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
0.000013 - 0.000188
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
0.032
2-phenyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-1,3-thiazole-5-carbohydrazide
Escherichia coli
-
pH 8.0, 37°C
0.03
3-bromo-N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)benzamide
Escherichia coli
-
pH 8.0, 37°C
0.0023
5-methyl-N-([4-(5-phenyl-1-benzofuran-2-yl)phenyl]sulfonyl)thiophene-2-carboxamide
Escherichia coli
-
Compound A, IC50 2.3 microM
0.027
N-(2-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-4-nitrobenzamide
Escherichia coli
-
pH 8.0, 37°C
0.031
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-2-naphthamide
Escherichia coli
-
pH 8.0, 37°C
0.051
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-2-nitrobenzamide
Escherichia coli
-
pH 8.0, 37°C
0.0000005
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
Pseudomonas aeruginosa
-
below, pH and temperature not specified in the publication
0.000002
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.0000007
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
Pseudomonas aeruginosa
-
pH 8.0, 25°C, recombinant enzyme
0.000012
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
Escherichia coli
-
pH 8.0, 25°C, recombinant enzyme
0.0000012
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000015
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.000008
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000057
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.0000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
Pseudomonas aeruginosa
-
below, pH and temperature not specified in the publication
0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.000007
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.00006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000021
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.000008
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.00004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.000001
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.0000007
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
Escherichia coli
-
pH and temperature not specified in the publication
0.000002
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000003
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
Escherichia coli
-
pH and temperature not specified in the publication
0.0000006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
Escherichia coli
-
pH and temperature not specified in the publication
0.000006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000052
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
Escherichia coli
-
pH and temperature not specified in the publication
0.000001
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
Escherichia coli
-
pH and temperature not specified in the publication
0.0000013
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000007
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.00006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
Escherichia coli
-
pH and temperature not specified in the publication
0.0000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
Pseudomonas aeruginosa
-
below, pH and temperature not specified in the publication
0.000003
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
Escherichia coli
-
pH and temperature not specified in the publication
0.000008
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000011
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.000011
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000101
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
0.000013
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000188
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
Escherichia coli
-
pH and temperature not specified in the publication
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evolution
-
the ORF with the locus tag VspiD_010100018130, encodes the enzymes UDP-N-acetylenolpyruvoylglucosamine reductase (MurB, EC 1.3.1.98) and UDP-N-acetylmuramate:L-alanine ligase (MurC), i.e. MurB/CVs, DNA and amino acid sequence determination and analysis, this fusion enzyme can only be identified in specific lineages within the Verrucomicrobia phylum. Unusual MurB and MurC composition is prevalent in currently sequenced members of Verrucomicrobia
evolution
-
the ORF with the locus tag VspiD_010100018130, encodes the enzymes UDP-N-acetylenolpyruvoylglucosamine reductase (MurB, EC 1.3.1.98) and UDP-N-acetylmuramate:L-alanine ligase (MurC), i.e. MurB/CVs, DNA and amino acid sequence determination and analysis, this fusion enzyme can only be identified in specific lineages within the Verrucomicrobia phylum. Unusual MurB and MurC composition is prevalent in currently sequenced members of Verrucomicrobia
-
malfunction
mutation of the gene murC impairs heterocyst differentiation in Nostoc sp. PCC 7120. Gene murC depletion leads to aberrant expression of patS in all cells of the filament
malfunction
-
UDP-N-acetylmuramic acid L-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death. The mutant strain shows accumulation of the MurC substrate and a decrease in the level of product upon treatment with (2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol, indicating inhibition of MurC enzyme in these cells. Overexpression of wild-type MurC in the Escherichia coli tolC mutant leads to an increase in the compound A MIC by over 16fold, establishing a correlation between MurC inhibition and cellular activity
malfunction
Nostoc sp. PCC 7120 = FACHB-418 SAG 25.82 / UTEX 2576
-
mutation of the gene murC impairs heterocyst differentiation in Nostoc sp. PCC 7120. Gene murC depletion leads to aberrant expression of patS in all cells of the filament
-
metabolism
enzyme MurC catalyzes the third step in peptidoglycan biosynthesis
metabolism
-
the enzyme is essentially involved in the bacterial peptidoglycan biosynthesis pathway. MurC, the first of four Mur ligases, ligates L-alanine to UDP-N-acetylmuramic acid, initiating the synthesis of pentapeptide precursor
metabolism
-
the enzyme is essentially involved in the bacterial peptidoglycan biosynthesis pathway. MurC, the first of four Mur ligases, ligates L-alanine to UDP-N-acetylmuramic acid, initiating the synthesis of pentapeptide precursor
metabolism
-
the enzyme MurB/CVs is involved in the cytoplasmic steps of peptidoglycan biosynthesis catalyzing the second and third step of the pathway, overview
metabolism
-
the enzyme MurB/CVs is involved in the cytoplasmic steps of peptidoglycan biosynthesis catalyzing the second and third step of the pathway, overview
-
metabolism
-
the enzyme is essentially involved in the bacterial peptidoglycan biosynthesis pathway. MurC, the first of four Mur ligases, ligates L-alanine to UDP-N-acetylmuramic acid, initiating the synthesis of pentapeptide precursor
-
metabolism
Nostoc sp. PCC 7120 = FACHB-418 SAG 25.82 / UTEX 2576
-
enzyme MurC catalyzes the third step in peptidoglycan biosynthesis
-
physiological function
-
ATP-dependent Mur ligases play essential roles in the biosynthesis of cell wall peptidoglycan as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis
physiological function
-
the enzyme is essential for peptidoglycan biosynthesis. Peptidoglycan is an essential cell wall component of both gram-positive and gram-negative bacteria that protects the cytoplasmic membrane from osmotic stress
physiological function
-
the enzyme is essential for peptidoglycan biosynthesis. Peptidoglycan is an essential cell wall component of both gram-positive and gram-negative bacteria that protects the cytoplasmic membrane from osmotic stress
physiological function
the enzyme is important in peptidoglycan biosynthesis. Heterocyst development has been shown to require proper peptidoglycan remodeling. Determination of a direct link between peptidoglycan synthesis and the maintenance of a biological pattern in a multicellular organism. Nostoc sp. PCC 7120 differentiates a periodic pattern of specialized heterocyst cells, requiring peptidoglycan synthesis by the murine ligase genes murC (alr5065) and murB (alr5066) for maintenance of patterned gene expression, filament integrity, and overall development, overview
physiological function
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the fusion gene encoding MurB/CVs is able to complement Escherichia coli murB and murC temperature-sensitive mutants
physiological function
-
the fusion gene encoding MurB/CVs is able to complement Escherichia coli murB and murC temperature-sensitive mutants
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physiological function
-
the enzyme is essential for peptidoglycan biosynthesis. Peptidoglycan is an essential cell wall component of both gram-positive and gram-negative bacteria that protects the cytoplasmic membrane from osmotic stress
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physiological function
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ATP-dependent Mur ligases play essential roles in the biosynthesis of cell wall peptidoglycan as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis
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physiological function
Nostoc sp. PCC 7120 = FACHB-418 SAG 25.82 / UTEX 2576
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the enzyme is important in peptidoglycan biosynthesis. Heterocyst development has been shown to require proper peptidoglycan remodeling. Determination of a direct link between peptidoglycan synthesis and the maintenance of a biological pattern in a multicellular organism. Nostoc sp. PCC 7120 differentiates a periodic pattern of specialized heterocyst cells, requiring peptidoglycan synthesis by the murine ligase genes murC (alr5065) and murB (alr5066) for maintenance of patterned gene expression, filament integrity, and overall development, overview
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additional information
MurC substrate binding site structures and three-dimensional structure modeling by homology modeling method, structure comparisons of Mur ligases, detailed overview. Identification of residues playing an important role in the catalytic activity of each of the Mur enzymes, docking of enzyme and substrate and ATP
additional information
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protein-protein interaction network of MurC, D, E, and F synthetases, overview
additional information
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protein-protein interaction network of MurC, D, E, and F synthetases, overview
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2016
Nostoc sp. PCC 7120 = FACHB-418 (Q8YM75), Nostoc sp. PCC 7120 = FACHB-418 SAG 25.82 / UTEX 2576 (Q8YM75)
brenda